Evaluation of racial differences in resting and postprandial endothelial function in postmenopausal women matched for age, fitness and body composition

Damon L. Swift, Judith Y. Weltman, James T. Patrie, Eugene J. Barrett, Glenn Gaesser, Arthur Weltman

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: We investigated endothelial function at rest and after a high-fat meal challenge in African American (AA) and Caucasian postmenopausal women matched for age, body mass index, percent fat and fitness level. Design: Pilot study. Setting: University of Virginia General Clinical Research Center. Participants: Eight AA and 8 Caucasian postmenopausal women. Intervention: Participants underwent a VO2 peak treadmill protocol, percent fat assessment, and brachial artery flow-mediated dilation measurements (baseline and 4 hours following a high-fat meal). Main outcomes measures: Baseline and postprandial flow mediated dilation (FMD) following a high-fat meal. Results: FMD values were similar in AA (5.4%, 95% CI: 3.3, 7.4) and Caucasian women (4.0%, 95% CI: 2.0, 6.1). There was no significant change in FMD from baseline to four hours following the meal challenge within groups (AA:. 9%, P=.397, Caucasian: 2.3%, P=.063) or between groups (P=.449), despite a significant increase in triglycerides (AA: 81.8 mg/dL, P<.001, Caucasian: 99.7 mg/dL, P -.004). Conclusions: The present pilot study found that when postmenopausal AA and Caucasian women are matched for age, fitness and body composition, reported racial differences in resting endothelial function were not observed. Additionally, there were no racial differences in postprandial endothelial function or metabolism following a high-fat meal.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalEthnicity and Disease
Volume23
Issue number1
StatePublished - Dec 2013
Externally publishedYes

Fingerprint

Body Composition
African Americans
Fats
Meals
Dilatation
Brachial Artery
Triglycerides
Body Mass Index
Outcome Assessment (Health Care)
Research

Keywords

  • African American
  • Endothelial function
  • Flow-mediated dilation
  • Postmenopausal
  • Postprandial
  • Racial differences

ASJC Scopus subject areas

  • Epidemiology
  • Medicine(all)

Cite this

Evaluation of racial differences in resting and postprandial endothelial function in postmenopausal women matched for age, fitness and body composition. / Swift, Damon L.; Weltman, Judith Y.; Patrie, James T.; Barrett, Eugene J.; Gaesser, Glenn; Weltman, Arthur.

In: Ethnicity and Disease, Vol. 23, No. 1, 12.2013, p. 43-48.

Research output: Contribution to journalArticle

Swift, Damon L. ; Weltman, Judith Y. ; Patrie, James T. ; Barrett, Eugene J. ; Gaesser, Glenn ; Weltman, Arthur. / Evaluation of racial differences in resting and postprandial endothelial function in postmenopausal women matched for age, fitness and body composition. In: Ethnicity and Disease. 2013 ; Vol. 23, No. 1. pp. 43-48.
@article{55a99d97fa784d22a87f01338d05c0e9,
title = "Evaluation of racial differences in resting and postprandial endothelial function in postmenopausal women matched for age, fitness and body composition",
abstract = "Objective: We investigated endothelial function at rest and after a high-fat meal challenge in African American (AA) and Caucasian postmenopausal women matched for age, body mass index, percent fat and fitness level. Design: Pilot study. Setting: University of Virginia General Clinical Research Center. Participants: Eight AA and 8 Caucasian postmenopausal women. Intervention: Participants underwent a VO2 peak treadmill protocol, percent fat assessment, and brachial artery flow-mediated dilation measurements (baseline and 4 hours following a high-fat meal). Main outcomes measures: Baseline and postprandial flow mediated dilation (FMD) following a high-fat meal. Results: FMD values were similar in AA (5.4{\%}, 95{\%} CI: 3.3, 7.4) and Caucasian women (4.0{\%}, 95{\%} CI: 2.0, 6.1). There was no significant change in FMD from baseline to four hours following the meal challenge within groups (AA:. 9{\%}, P=.397, Caucasian: 2.3{\%}, P=.063) or between groups (P=.449), despite a significant increase in triglycerides (AA: 81.8 mg/dL, P<.001, Caucasian: 99.7 mg/dL, P -.004). Conclusions: The present pilot study found that when postmenopausal AA and Caucasian women are matched for age, fitness and body composition, reported racial differences in resting endothelial function were not observed. Additionally, there were no racial differences in postprandial endothelial function or metabolism following a high-fat meal.",
keywords = "African American, Endothelial function, Flow-mediated dilation, Postmenopausal, Postprandial, Racial differences",
author = "Swift, {Damon L.} and Weltman, {Judith Y.} and Patrie, {James T.} and Barrett, {Eugene J.} and Glenn Gaesser and Arthur Weltman",
year = "2013",
month = "12",
language = "English (US)",
volume = "23",
pages = "43--48",
journal = "Ethnicity and Disease",
issn = "1049-510X",
publisher = "ISHIB",
number = "1",

}

TY - JOUR

T1 - Evaluation of racial differences in resting and postprandial endothelial function in postmenopausal women matched for age, fitness and body composition

AU - Swift, Damon L.

AU - Weltman, Judith Y.

AU - Patrie, James T.

AU - Barrett, Eugene J.

AU - Gaesser, Glenn

AU - Weltman, Arthur

PY - 2013/12

Y1 - 2013/12

N2 - Objective: We investigated endothelial function at rest and after a high-fat meal challenge in African American (AA) and Caucasian postmenopausal women matched for age, body mass index, percent fat and fitness level. Design: Pilot study. Setting: University of Virginia General Clinical Research Center. Participants: Eight AA and 8 Caucasian postmenopausal women. Intervention: Participants underwent a VO2 peak treadmill protocol, percent fat assessment, and brachial artery flow-mediated dilation measurements (baseline and 4 hours following a high-fat meal). Main outcomes measures: Baseline and postprandial flow mediated dilation (FMD) following a high-fat meal. Results: FMD values were similar in AA (5.4%, 95% CI: 3.3, 7.4) and Caucasian women (4.0%, 95% CI: 2.0, 6.1). There was no significant change in FMD from baseline to four hours following the meal challenge within groups (AA:. 9%, P=.397, Caucasian: 2.3%, P=.063) or between groups (P=.449), despite a significant increase in triglycerides (AA: 81.8 mg/dL, P<.001, Caucasian: 99.7 mg/dL, P -.004). Conclusions: The present pilot study found that when postmenopausal AA and Caucasian women are matched for age, fitness and body composition, reported racial differences in resting endothelial function were not observed. Additionally, there were no racial differences in postprandial endothelial function or metabolism following a high-fat meal.

AB - Objective: We investigated endothelial function at rest and after a high-fat meal challenge in African American (AA) and Caucasian postmenopausal women matched for age, body mass index, percent fat and fitness level. Design: Pilot study. Setting: University of Virginia General Clinical Research Center. Participants: Eight AA and 8 Caucasian postmenopausal women. Intervention: Participants underwent a VO2 peak treadmill protocol, percent fat assessment, and brachial artery flow-mediated dilation measurements (baseline and 4 hours following a high-fat meal). Main outcomes measures: Baseline and postprandial flow mediated dilation (FMD) following a high-fat meal. Results: FMD values were similar in AA (5.4%, 95% CI: 3.3, 7.4) and Caucasian women (4.0%, 95% CI: 2.0, 6.1). There was no significant change in FMD from baseline to four hours following the meal challenge within groups (AA:. 9%, P=.397, Caucasian: 2.3%, P=.063) or between groups (P=.449), despite a significant increase in triglycerides (AA: 81.8 mg/dL, P<.001, Caucasian: 99.7 mg/dL, P -.004). Conclusions: The present pilot study found that when postmenopausal AA and Caucasian women are matched for age, fitness and body composition, reported racial differences in resting endothelial function were not observed. Additionally, there were no racial differences in postprandial endothelial function or metabolism following a high-fat meal.

KW - African American

KW - Endothelial function

KW - Flow-mediated dilation

KW - Postmenopausal

KW - Postprandial

KW - Racial differences

UR - http://www.scopus.com/inward/record.url?scp=84873335839&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873335839&partnerID=8YFLogxK

M3 - Article

C2 - 23495621

AN - SCOPUS:84873335839

VL - 23

SP - 43

EP - 48

JO - Ethnicity and Disease

JF - Ethnicity and Disease

SN - 1049-510X

IS - 1

ER -