Evaluation of limonoids against the murine p388 lymphocytic leukemia cell line

George Pettit, Derek H R Barton, Cherry L. Herald, Judith Polonsky, Jean M. Schmidt, Joseph D. Connolly

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

A structure/activity study of selected limonoids from two plant families (Meliaceae and Rutaceae) of the Rutales order against the murine P-388 lymphocytic leukemia system was undertaken. The presence of both a 19-28 lactol and a 14,15(i-epoxide group was found especially important for pronounced inhibition of the PS in vitro cell line. Substitution of an A-ring α,β-unsaturated ketone (3-oxo- 1-ene) for the lactol led to diminished activity, while reduction of the olefin caused complete loss of activity. At the dose levels employed, even very good PS in vitro inhibition was not translated into PS in vivo antineoplastic effects.

Original languageEnglish (US)
Pages (from-to)379-390
Number of pages12
JournalJournal of Natural Products
Volume46
Issue number3
DOIs
StatePublished - May 1983

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Pettit, G., Barton, D. H. R., Herald, C. L., Polonsky, J., Schmidt, J. M., & Connolly, J. D. (1983). Evaluation of limonoids against the murine p388 lymphocytic leukemia cell line. Journal of Natural Products, 46(3), 379-390. https://doi.org/10.1021/np50027a015