Evaluating the predictive power of multivariate tensor-based morphometry in Alzheimer's disease progression via convex fused sparse group Lasso

Sinchai Tsao, Niharika Gajawelli, Jiayu Zhou, Jie Shi, Jieping Ye, Yalin Wang, Natasha Lepore

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Prediction of Alzheimers disease (AD) progression based on baseline measures allows us to understand disease progression and has implications in decisions concerning treatment strategy. To this end we combine a predictive multi-task machine learning method1 with novel MR-based multivariate morphometric surface map of the hippocampus2 to predict future cognitive scores of patients. Previous work by Zhou et al.1 has shown that a multi-task learning framework that performs prediction of all future time points (or tasks) simultaneously can be used to encode both sparsity as well as temporal smoothness. They showed that this can be used in predicting cognitive outcomes of Alzheimers Disease Neuroimaging Initiative (ADNI) subjects based on FreeSurfer-based baseline MRI features, MMSE score demographic information and ApoE status. Whilst volumetric information may hold generalized information on brain status, we hypothesized that hippocampus specific information may be more useful in predictive modeling of AD. To this end, we applied Shi et al.2s recently developed multivariate tensor-based (mTBM) parametric surface analysis method to extract features from the hippocampal surface. We show that by combining the power of the multi-task framework with the sensitivity of mTBM features of the hippocampus surface, we are able to improve significantly improve predictive performance of ADAS cognitive scores 6, 12, 24, 36 and 48 months from baseline.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume9034
ISBN (Print)9780819498274
DOIs
StatePublished - 2014
EventMedical Imaging 2014: Image Processing - San Diego, CA, United States
Duration: Feb 16 2014Feb 18 2014

Other

OtherMedical Imaging 2014: Image Processing
CountryUnited States
CitySan Diego, CA
Period2/16/142/18/14

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progressions
Tensors
Disease Progression
Alzheimer Disease
tensors
hippocampus
Hippocampus
Apolipoproteins E
Neuroimaging
machine learning
Surface analysis
predictions
Demography
Learning
Magnetic resonance imaging
learning
brain
Learning systems
Brain
alachlor

Keywords

  • ADAS-Cog
  • Alzheimers Disease
  • Disease Progression
  • Feature Selection
  • Fused Lasso
  • Hippocampus
  • Multi-task learning
  • Tensor-based Morphometry

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Tsao, S., Gajawelli, N., Zhou, J., Shi, J., Ye, J., Wang, Y., & Lepore, N. (2014). Evaluating the predictive power of multivariate tensor-based morphometry in Alzheimer's disease progression via convex fused sparse group Lasso. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 9034). [90342L] SPIE. https://doi.org/10.1117/12.2042720

Evaluating the predictive power of multivariate tensor-based morphometry in Alzheimer's disease progression via convex fused sparse group Lasso. / Tsao, Sinchai; Gajawelli, Niharika; Zhou, Jiayu; Shi, Jie; Ye, Jieping; Wang, Yalin; Lepore, Natasha.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9034 SPIE, 2014. 90342L.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tsao, S, Gajawelli, N, Zhou, J, Shi, J, Ye, J, Wang, Y & Lepore, N 2014, Evaluating the predictive power of multivariate tensor-based morphometry in Alzheimer's disease progression via convex fused sparse group Lasso. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 9034, 90342L, SPIE, Medical Imaging 2014: Image Processing, San Diego, CA, United States, 2/16/14. https://doi.org/10.1117/12.2042720
Tsao S, Gajawelli N, Zhou J, Shi J, Ye J, Wang Y et al. Evaluating the predictive power of multivariate tensor-based morphometry in Alzheimer's disease progression via convex fused sparse group Lasso. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9034. SPIE. 2014. 90342L https://doi.org/10.1117/12.2042720
Tsao, Sinchai ; Gajawelli, Niharika ; Zhou, Jiayu ; Shi, Jie ; Ye, Jieping ; Wang, Yalin ; Lepore, Natasha. / Evaluating the predictive power of multivariate tensor-based morphometry in Alzheimer's disease progression via convex fused sparse group Lasso. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9034 SPIE, 2014.
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