This work aims to investigate the effects of knee extension assistance during squat lifting. We hypothesize that adding an external torque to the knee joint using a soft inflatable exosuit can potentially induce a reduction in the muscular effort that extends to the posterior chain muscles. A total of 8 healthy test participants are recruited and instructed to lift a weight equivalent to 10% of their bodyweight. The muscle activities of the left and right Vastus Lateralis, Biceps Femoris, Gluteus Maximus, Erector Spinae (Iliocostalis and Longissimus) and Multifidus muscle groups were studied for baseline, non-Assisted, and assisted conditions. The majority of participants (6 out of 8) demonstrated consistent reduction in the muscular effort of at least one muscle group of the posterior chain. A maximum reduction of 55% in the average muscle activity of the Multifidus muscle group is observed in one participant. Different neuromuscular adaptation mechanisms were observed among subjects that ultimately led to a reduction in lower-limb or back muscles activity. The results reveal that assisting knee extension during a lifting task has significant effects on muscle activity with benefits that extend to the posterior chain muscles. This work provides early evidence that the soft inflatable knee exosuit can be used in material handling tasks to reduce muscle effort and prevent work-related injuries.