Ethnicity, Cortisol, and Experimental Pain Responses among Persons with Symptomatic Knee Osteoarthritis

Matthew S. Herbert, Burel R. Goodin, Hailey W. Bulls, Adriana Sotolongo, Megan Petrov, Jeffrey C. Edberg, Laurence A. Bradley, Roger B. Fillingim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

OBJECTIVES:: While several factors are known to contribute to ethnic differences in pain, relatively little attention has been devoted to physiological factors. Our first aim was to examine the relationship between cortisol and pain responses during a cold-pressor task (CPT) among African American (AA) and non-Hispanic White (NHW) adults with knee osteoarthritis (OA). Our second aim was to assess the relationship between perceived racial discrimination and cortisol among AA participants. METHODS:: Participants were 91 (56 AA; 35 NHW) community-dwelling adults between the ages of 45 to 85 with knee OA based upon the American College of Rheumatology clinical criteria. Plasma cortisol was measured at 3 time points: (1) baseline, (2) prior to the CPT, and (3) 20-minutes following the CPT. Perceived racial discrimination was measured by the Experiences of Discrimination scale. RESULTS:: Using linear regression, we found a significant interaction between ethnicity and cortisol prior to the CPT with pain intensity ratings (β=−0.26; P=0.02). Analysis of simple slopes revealed that cortisol concentrations were negatively associated with pain intensity ratings in NHW participants (β=−0.54; P=0.001), but not in AA participants (β=−0.15; P=0.26). Perceived racial discrimination was not related to cortisol concentrations or pain ratings. DISCUSSION:: Consistent with previous findings in young healthy adults, cold pressor pain responses are related to pre-CPT cortisol concentrations in NHW persons with knee OA but not in their AA counterparts. Additional studies are required to better understand this finding.

Original languageEnglish (US)
JournalClinical Journal of Pain
DOIs
StateAccepted/In press - Nov 28 2016

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Knee Osteoarthritis
Hydrocortisone
African Americans
Pain
Racism
Independent Living
Young Adult
Linear Models

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

Ethnicity, Cortisol, and Experimental Pain Responses among Persons with Symptomatic Knee Osteoarthritis. / Herbert, Matthew S.; Goodin, Burel R.; Bulls, Hailey W.; Sotolongo, Adriana; Petrov, Megan; Edberg, Jeffrey C.; Bradley, Laurence A.; Fillingim, Roger B.

In: Clinical Journal of Pain, 28.11.2016.

Research output: Contribution to journalArticle

Herbert, Matthew S. ; Goodin, Burel R. ; Bulls, Hailey W. ; Sotolongo, Adriana ; Petrov, Megan ; Edberg, Jeffrey C. ; Bradley, Laurence A. ; Fillingim, Roger B. / Ethnicity, Cortisol, and Experimental Pain Responses among Persons with Symptomatic Knee Osteoarthritis. In: Clinical Journal of Pain. 2016.
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