OBJECTIVE- To assess whether lower adiponectin concentrations in South Asian Indians may be responsible for their greater degree of insulin resistance. RESEARCH DESIGN AND METHODS- Insulin-mediated glucose uptake and plasma total and high molecular weight (HMW) adiponectin concentrations were quantified in 52 women of South Asian (SA) and Caucasian (CAU) ancestry and compared. RESULTS- Mean ± SD total (2,965 ± 1,278 vs. 4,235 ± 160 ng/ml) and HMW (1,001 ± 352 vs. 1,591 ± 854 ng/ml) adiponectin were lower in SAs than CAUs (P < 0.005). Insulin- resistant CAUs (CAU-IR) had lower total (2,665 ± 1,040 vs. 5,133 ± 1,086 ng/ml) and HMW (987 ± 479 vs. 1,935 ± 838 ng/ml) adiponectin than insulin-sensitive CAUs (CAU-IS) (P < 0.01), but there were no significant differences between insulin-resistant (SA-IR) and insulinsensitive (SA-IS) SAs. HMW adiponectin did not differ between SA-IR and CAU-IR, but SA-IS had significantly lower adiponectin concentrations than CAU-IS. CONCLUSIONS- Insulin resistance status is not associated with significantly lower levels of adiponectin in these SA women, in contrast to the CAU women.
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Advanced and Specialized Nursing