Estrogen control of uterine tissue factor messenger ribonucleic acid levels

Katherine P. Henrikson, Jeffrey A. Greenwood, Brian T. Pentecost, Elena E. Jazinj, Herbert W. Dickerman

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

One of the early responses of the immature rat uterus to stimulation by estradiol (E2) is an increase in the specific activity and synthesis of a discrete set of proteins including tissue factor (TF). Increases in TF are associated with stimulation of cell growth in mouse and human fibroblasts and endothelial cells. The increase in TF activity following E2stimulation of the uterus is due to an increase in TF messenger RNA (mRNA). A 2- to 4-fold increase in mRNA is observed 1 h after injection, reaches a maximum at 3 h, and is reduced at 6 h. The increase is hormone specific and occurs at low levels of E2(0.66 Mg/kg). The E2 effect is abolished by actinomycin but not by cycloheximide. The changes in TF mRNA occur in a similar time scale and at similar E2doses as the increases in the uterine protooncogenes c-jun and c-fos.

Original languageEnglish (US)
Pages (from-to)2669-2674
Number of pages6
JournalEndocrinology
Volume130
Issue number5
DOIs
StatePublished - May 1992
Externally publishedYes

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Thromboplastin
Estrogens
RNA
Messenger RNA
Uterus
Dactinomycin
Cycloheximide
Estradiol
Endothelial Cells
Fibroblasts
Hormones
Injections
Growth
Proteins

ASJC Scopus subject areas

  • Endocrinology

Cite this

Henrikson, K. P., Greenwood, J. A., Pentecost, B. T., Jazinj, E. E., & Dickerman, H. W. (1992). Estrogen control of uterine tissue factor messenger ribonucleic acid levels. Endocrinology, 130(5), 2669-2674. https://doi.org/10.1210/endo.130.5.1374011

Estrogen control of uterine tissue factor messenger ribonucleic acid levels. / Henrikson, Katherine P.; Greenwood, Jeffrey A.; Pentecost, Brian T.; Jazinj, Elena E.; Dickerman, Herbert W.

In: Endocrinology, Vol. 130, No. 5, 05.1992, p. 2669-2674.

Research output: Contribution to journalArticle

Henrikson, KP, Greenwood, JA, Pentecost, BT, Jazinj, EE & Dickerman, HW 1992, 'Estrogen control of uterine tissue factor messenger ribonucleic acid levels', Endocrinology, vol. 130, no. 5, pp. 2669-2674. https://doi.org/10.1210/endo.130.5.1374011
Henrikson, Katherine P. ; Greenwood, Jeffrey A. ; Pentecost, Brian T. ; Jazinj, Elena E. ; Dickerman, Herbert W. / Estrogen control of uterine tissue factor messenger ribonucleic acid levels. In: Endocrinology. 1992 ; Vol. 130, No. 5. pp. 2669-2674.
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