Estimation of the marker gene frequency and linkage disequilibrium from conditional marker data

A. Chakravarti, C. C. Li, K. H. Buetow

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

A method is proposed to calculate the maximum likelihood estimate of gene frequency and linkage disequilibrium from disease-codominant marker conditional data. The method is illustrated using data on sickle-cell anemia and Duchenne muscular dystrophy and linked polymorphic restriction endonuclease cleavage sites.

Original languageEnglish (US)
Pages (from-to)177-186
Number of pages10
JournalAmerican Journal of Human Genetics
Volume36
Issue number1
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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