A method is proposed to calculate the maximum likelihood estimate of gene frequency and linkage disequilibrium from disease-codominant marker conditional data. The method is illustrated using data on sickle-cell anemia and Duchenne muscular dystrophy and linked polymorphic restriction endonuclease cleavage sites.
|Original language||English (US)|
|Number of pages||10|
|Journal||American Journal of Human Genetics|
|State||Published - Jan 1 1984|
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