Estimation of the marker gene frequency and linkage disequilibrium from conditional marker data

A. Chakravarti, C. C. Li, K. H. Buetow

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

A method is proposed to calculate the maximum likelihood estimate of gene frequency and linkage disequilibrium from disease-codominant marker conditional data. The method is illustrated using data on sickle-cell anemia and Duchenne muscular dystrophy and linked polymorphic restriction endonuclease cleavage sites.

Original languageEnglish (US)
Pages (from-to)177-186
Number of pages10
JournalAmerican Journal of Human Genetics
Volume36
Issue number1
StatePublished - Jan 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Estimation of the marker gene frequency and linkage disequilibrium from conditional marker data'. Together they form a unique fingerprint.

  • Cite this