Estimation of the marker gene frequency and linkage disequilibrium from conditional marker data

A. Chakravarti, C. C. Li, Kenneth Buetow

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A method is proposed to calculate the maximum likelihood estimate of gene frequency and linkage disequilibrium from disease-codominant marker conditional data. The method is illustrated using data on sickle-cell anemia and Duchenne muscular dystrophy and linked polymorphic restriction endonuclease cleavage sites.

Original languageEnglish (US)
Pages (from-to)177-186
Number of pages10
JournalAmerican Journal of Human Genetics
Volume36
Issue number1
StatePublished - 1984
Externally publishedYes

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Linkage Disequilibrium
Gene Frequency
Likelihood Functions
Duchenne Muscular Dystrophy
DNA Restriction Enzymes
Sickle Cell Anemia

ASJC Scopus subject areas

  • Genetics

Cite this

Estimation of the marker gene frequency and linkage disequilibrium from conditional marker data. / Chakravarti, A.; Li, C. C.; Buetow, Kenneth.

In: American Journal of Human Genetics, Vol. 36, No. 1, 1984, p. 177-186.

Research output: Contribution to journalArticle

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