Estimation of relative fitnesses from relative risk data and the predicted future of haemoglobin alleles S and C

P. Hedrick

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Epidemiological studies of genetic differences in disease susceptibility often estimate the relative risks (RR) of different genotypes. Here I provide an approach to calculate the relative fitnesses of different genotypes based on RR data so that population genetic approaches may be utilized with these data. Using recent RR data on human haemoglobin β genotypes from Burkina Faso, this approach is used to predict changes in the frequency of the haemoglobin sickle-cell S and C alleles. Overall, it generally appears that allele C will quickly replace the S allele in malarial environments. Explicit population genetic predictions suggest that this replacement may occur within the next 50 generations in Burkina Faso.

Original languageEnglish (US)
Pages (from-to)221-224
Number of pages4
JournalJournal of Evolutionary Biology
Volume17
Issue number1
DOIs
StatePublished - Jan 1 2004

Keywords

  • Malaria
  • Polymorphism
  • Relative risk
  • Sickle-cell

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics

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