Estimation of invasive pneumococcal disease dynamics parameters and the impact of conjugate vaccination in Australia

Karyn L. Sutton, H. T. Banks, Carlos Castillo-Chavez

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Pneumococcal diseases, or infections from the etiological agent Streptococcus pneumonias, have long been a major cause of morbidity and mortality worldwide. Recent advances in the development of vaccines for these infections have raised questions concerning their widespread and/or long-term use. In this work, we use surveillance data collected by the Australian National Notifiable Diseases Surveillance system to estimate parameters in a mathematical model of pneumococcal infection dynamics in a population with partial vaccination. The parameters obtained are of particular interest as they are not typically available in reported literature or measurable. The calibrated model is then used to assess the impact of the recent federally funded program that provides pneumococcal vaccines to large risk groups. The results presented here suggest the state of these infections may be changing in response to the programs, and warrants close quantitative monitoring.

Original languageEnglish (US)
Pages (from-to)175-204
Number of pages30
JournalMathematical Biosciences and Engineering
Volume5
Issue number1
DOIs
StatePublished - Jan 2008

Keywords

  • Inverse problems
  • Pneumococcal infection dynamics
  • Population model
  • Statistical methods

ASJC Scopus subject areas

  • Modeling and Simulation
  • Agricultural and Biological Sciences(all)
  • Computational Mathematics
  • Applied Mathematics

Fingerprint Dive into the research topics of 'Estimation of invasive pneumococcal disease dynamics parameters and the impact of conjugate vaccination in Australia'. Together they form a unique fingerprint.

  • Cite this