Estimating the number of granule cells in the dentate gyrus with the disector

Mark J. West, Paul D. Coleman, Dorothy G. Flood

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

A practical example is given of how a newly developed stereological estimator of particle number, the disector, can be used to make estimates of neuron number in the dentate gyrus of rats. The estimates are free of biases related to lost caps, overprojection and assumptions about size, shape and orientation of the objects that are counted. The disector principle and the practical considerations relating to histological preparations and sampling are presented.

Original languageEnglish (US)
Pages (from-to)167-172
Number of pages6
JournalBrain Research
Volume448
Issue number1
DOIs
StatePublished - May 10 1988
Externally publishedYes

Keywords

  • Dentate gyrus
  • Disector
  • Granule cell
  • Morphometrics
  • Stereology

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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