Estimating the number of granule cells in the dentate gyrus with the disector

Mark J. West; Paul D. Coleman; Dorothy G. Flood

doi:10.1016/0006-8993(88)91114-6

Estimating the number of granule cells in the dentate gyrus with the disector

Mark J. West, Paul D. Coleman, Dorothy G. Flood

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

A practical example is given of how a newly developed stereological estimator of particle number, the disector, can be used to make estimates of neuron number in the dentate gyrus of rats. The estimates are free of biases related to lost caps, overprojection and assumptions about size, shape and orientation of the objects that are counted. The disector principle and the practical considerations relating to histological preparations and sampling are presented.

Original language	English (US)
Pages (from-to)	167-172
Number of pages	6
Journal	Brain Research
Volume	448
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(88)91114-6
State	Published - May 10 1988
Externally published	Yes

Keywords

Dentate gyrus
Disector
Granule cell
Morphometrics
Stereology

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(88)91114-6

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AB - A practical example is given of how a newly developed stereological estimator of particle number, the disector, can be used to make estimates of neuron number in the dentate gyrus of rats. The estimates are free of biases related to lost caps, overprojection and assumptions about size, shape and orientation of the objects that are counted. The disector principle and the practical considerations relating to histological preparations and sampling are presented.

KW - Dentate gyrus

KW - Disector

KW - Granule cell

KW - Morphometrics

KW - Stereology

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Estimating the number of granule cells in the dentate gyrus with the disector

Abstract

Keywords

ASJC Scopus subject areas

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