Error filtration, interference, and the human linkage map

D. C. Shields; A. Collins; K. H. Buetow; N. E. Morton

doi:10.1073/pnas.88.15.6501

Error filtration, interference, and the human linkage map

D. C. Shields, A. Collins, K. H. Buetow, N. E. Morton

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Typing error is a major problem in constructing human linkage maps, leading to incorrect orders and inflating map lengths. An error filter is incorporated into multiple pairwise analysis that corrects for inflation of map lengths and improves recovery of the correct order. Multipoint mapping is more sensitive to error, but when its output is adjusted for both error and interference, map lengths are no longer inflated in proportion to the number of loci and are close to those obtained by multiple pairwise analysis.

Original language	English (US)
Pages (from-to)	6501-6505
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	88
Issue number	15
DOIs	https://doi.org/10.1073/pnas.88.15.6501
State	Published - 1991
Externally published	Yes

Keywords

gene map
genetic linkage
human genome

ASJC Scopus subject areas

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10.1073/pnas.88.15.6501

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AU - Collins, A.

AU - Buetow, K. H.

AU - Morton, N. E.

PY - 1991

Y1 - 1991

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AB - Typing error is a major problem in constructing human linkage maps, leading to incorrect orders and inflating map lengths. An error filter is incorporated into multiple pairwise analysis that corrects for inflation of map lengths and improves recovery of the correct order. Multipoint mapping is more sensitive to error, but when its output is adjusted for both error and interference, map lengths are no longer inflated in proportion to the number of loci and are close to those obtained by multiple pairwise analysis.

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KW - genetic linkage

KW - human genome

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Error filtration, interference, and the human linkage map

Abstract

Keywords

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