Error filtration, interference, and the human linkage map

D. C. Shields, A. Collins, K. H. Buetow, N. E. Morton

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Typing error is a major problem in constructing human linkage maps, leading to incorrect orders and inflating map lengths. An error filter is incorporated into multiple pairwise analysis that corrects for inflation of map lengths and improves recovery of the correct order. Multipoint mapping is more sensitive to error, but when its output is adjusted for both error and interference, map lengths are no longer inflated in proportion to the number of loci and are close to those obtained by multiple pairwise analysis.

Original languageEnglish (US)
Pages (from-to)6501-6505
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume88
Issue number15
DOIs
StatePublished - Sep 4 1991

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Keywords

  • gene map
  • genetic linkage
  • human genome

ASJC Scopus subject areas

  • General

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