Epigenetics of cognition and neurodegenerative disorders

Paul Coleman; Matthew Huentelman; Travis Dunckley

doi:10.1007/978-1-4939-2159-1_10

Epigenetics of cognition and neurodegenerative disorders

Paul Coleman, Matthew Huentelman, Travis Dunckley

ASU-Banner Neurodegenerative Disease Research Center (NDRC)

Research output: Contribution to journal › Article › peer-review

Abstract

Epigenetics is defined as alterations in RNA transcript expression, or the phenotype of the cell, that are caused by mechanisms other than changes in the associated DNA sequence. This chapter focuses on the general process of gene transcription. It also discusses how epigenetics intervenes in this process, the heritability of cognitive performance, as well as relations between cognition and DNA methylation, histone and chromatin changes, and micro RNAs. In addition, also summarized here is the current state of knowledge surrounding the role of epigenetics in the most common neurodegenerative diseases. Highlighted are the complex regulatory networks at play in the healthy and diseased nervous system, and the tenet that the research fi ndings are promising and suggest new therapeutic avenues.

Original language	English (US)
Pages (from-to)	285-298
Number of pages	14
Journal	Neuromethods
Volume	94
DOIs	https://doi.org/10.1007/978-1-4939-2159-1_10
State	Published - 2015

Keywords

Animal model
Behavior
Brain
DNA
Disease
Epigenetics
Genetic
Learning
Memory
Mutation
Neurodegeneration
Pathology
RNA

ASJC Scopus subject areas

Psychiatry and Mental health
General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology
General Neuroscience

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10.1007/978-1-4939-2159-1_10

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title = "Epigenetics of cognition and neurodegenerative disorders",

abstract = "Epigenetics is defined as alterations in RNA transcript expression, or the phenotype of the cell, that are caused by mechanisms other than changes in the associated DNA sequence. This chapter focuses on the general process of gene transcription. It also discusses how epigenetics intervenes in this process, the heritability of cognitive performance, as well as relations between cognition and DNA methylation, histone and chromatin changes, and micro RNAs. In addition, also summarized here is the current state of knowledge surrounding the role of epigenetics in the most common neurodegenerative diseases. Highlighted are the complex regulatory networks at play in the healthy and diseased nervous system, and the tenet that the research fi ndings are promising and suggest new therapeutic avenues.",

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AU - Huentelman, Matthew

AU - Dunckley, Travis

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AB - Epigenetics is defined as alterations in RNA transcript expression, or the phenotype of the cell, that are caused by mechanisms other than changes in the associated DNA sequence. This chapter focuses on the general process of gene transcription. It also discusses how epigenetics intervenes in this process, the heritability of cognitive performance, as well as relations between cognition and DNA methylation, histone and chromatin changes, and micro RNAs. In addition, also summarized here is the current state of knowledge surrounding the role of epigenetics in the most common neurodegenerative diseases. Highlighted are the complex regulatory networks at play in the healthy and diseased nervous system, and the tenet that the research fi ndings are promising and suggest new therapeutic avenues.

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Epigenetics of cognition and neurodegenerative disorders

Abstract

Keywords

ASJC Scopus subject areas

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