Epigenetics of cognition and neurodegenerative disorders

Paul Coleman, Matthew Huentelman, Travis Dunckley

Research output: Contribution to journalArticlepeer-review

Abstract

Epigenetics is defined as alterations in RNA transcript expression, or the phenotype of the cell, that are caused by mechanisms other than changes in the associated DNA sequence. This chapter focuses on the general process of gene transcription. It also discusses how epigenetics intervenes in this process, the heritability of cognitive performance, as well as relations between cognition and DNA methylation, histone and chromatin changes, and micro RNAs. In addition, also summarized here is the current state of knowledge surrounding the role of epigenetics in the most common neurodegenerative diseases. Highlighted are the complex regulatory networks at play in the healthy and diseased nervous system, and the tenet that the research fi ndings are promising and suggest new therapeutic avenues.

Original languageEnglish (US)
Pages (from-to)285-298
Number of pages14
JournalNeuromethods
Volume94
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • Animal model
  • Behavior
  • Brain
  • DNA
  • Disease
  • Epigenetics
  • Genetic
  • Learning
  • Memory
  • Mutation
  • Neurodegeneration
  • Pathology
  • RNA

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health

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