Epigenetic mechanisms in Alzheimer's disease

Diego Mastroeni, Andrew Grover, Elaine Delvaux, Charisse Whiteside, Paul D. Coleman, Joseph Rogers

Research output: Contribution to journalReview article

169 Scopus citations

Abstract

Epigenetic modifications help orchestrate sweeping developmental, aging, and disease-causing changes in phenotype by altering transcriptional activity in multiple genes spanning multiple biologic pathways. Although previous epigenetic research has focused primarily on dividing cells, particularly in cancer, recent studies have shown rapid, dynamic, and persistent epigenetic modifications in neurons that have significant neuroendocrine, neurophysiologic, and neurodegenerative consequences. Here, we provide a review of the major mechanisms for epigenetic modification and how they are reportedly altered in aging and Alzheimer's disease (AD). Because of their reach across the genome, epigenetic mechanisms may provide a unique integrative framework for the pathologic diversity and complexity of AD.

Original languageEnglish (US)
Pages (from-to)1161-1180
Number of pages20
JournalNeurobiology of Aging
Volume32
Issue number7
DOIs
StatePublished - Jul 1 2011
Externally publishedYes

Keywords

  • Amyloid β peptide
  • Cell cycle
  • DNA methylation
  • Epigenetics
  • Gene expression
  • Genetics
  • Histone acetylation
  • Inflammation
  • MiRNA
  • Oxidative stress
  • RDNA

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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