Epicardial adipose thickness in youth with type 1 diabetes

Background and Objective: Epicardial adipose thickness (EAT) is increased in adults with type 1 diabetes (T1D) and is thought to contribute to cardiovascular disease (CVD) in this population. Given that CVD risk factors emerge early in life, the purpose of this study was to identify whether EAT is increased in pediatric patients with T1D compared with non-diabetic controls. Methods: Anthropometric data, blood pressure (BP), and EAT were evaluated in 20 youth with T1D and 20 age, sex, and body mass index (BMI) matched healthy controls between the ages of 5 and 18 years. Results: EAT was 18.5% higher among youth with T1D compared to healthy controls (1.65 ± 0.44 mm vs 1.37 ± 0.27 mm, P =.02). In the entire cohort, EAT was correlated with age (r = 0.71, P '.001), BMI (r =.69, P '.001), waist circumference (r = 0.60, P '.001), systolic BP (r =.34, P =.03), and diastolic BP (r = 0.41, P =.009). Among youth with T1D, there were no significant correlations between EAT and HbA1c (r = −0.16, P =.50), insulin dose (r =.09, P =.71), or duration of disease (r = 0.06, P =.82). Conclusions: Youth with T1D exhibited significantly higher EAT compared to controls. Increased EAT was associated with adiposity and BP, but not duration of disease, insulin dose, or glycemic control. Increased EAT may represent a pathophysiologic mechanism leading to premature CVD in pediatric patients with T1D.