Epicardial adipose thickness in youth with type 1 diabetes

Melissa A. Chambers, Gabriel Shaibi, Chirag R. Kapadia, Kiley B. Vander Wyst, Amanda Campos, Janiel Pimentel, Robert F. Gonsalves, Bryan M. Sandweiss, Micah L. Olson

Research output: Contribution to journalArticle

Abstract

Background and Objective: Epicardial adipose thickness (EAT) is increased in adults with type 1 diabetes (T1D) and is thought to contribute to cardiovascular disease (CVD) in this population. Given that CVD risk factors emerge early in life, the purpose of this study was to identify whether EAT is increased in pediatric patients with T1D compared with non-diabetic controls. Methods: Anthropometric data, blood pressure (BP), and EAT were evaluated in 20 youth with T1D and 20 age, sex, and body mass index (BMI) matched healthy controls between the ages of 5 and 18 years. Results: EAT was 18.5% higher among youth with T1D compared to healthy controls (1.65 ± 0.44 mm vs 1.37 ± 0.27 mm, P =.02). In the entire cohort, EAT was correlated with age (r = 0.71, P <.001), BMI (r =.69, P <.001), waist circumference (r = 0.60, P <.001), systolic BP (r =.34, P =.03), and diastolic BP (r = 0.41, P =.009). Among youth with T1D, there were no significant correlations between EAT and HbA1c (r = −0.16, P =.50), insulin dose (r =.09, P =.71), or duration of disease (r = 0.06, P =.82). Conclusions: Youth with T1D exhibited significantly higher EAT compared to controls. Increased EAT was associated with adiposity and BP, but not duration of disease, insulin dose, or glycemic control. Increased EAT may represent a pathophysiologic mechanism leading to premature CVD in pediatric patients with T1D.

Original languageEnglish (US)
JournalPediatric Diabetes
DOIs
StatePublished - Jan 1 2019

Fingerprint

Type 1 Diabetes Mellitus
Blood Pressure
Cardiovascular Diseases
Body Mass Index
Insulin
Pediatrics
Adiposity
Waist Circumference
Population

Keywords

  • adipose tissue
  • adolescent
  • cardiovascular diseases
  • diabetes mellitus, type 1
  • risk factors

ASJC Scopus subject areas

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

Cite this

Chambers, M. A., Shaibi, G., Kapadia, C. R., Vander Wyst, K. B., Campos, A., Pimentel, J., ... Olson, M. L. (2019). Epicardial adipose thickness in youth with type 1 diabetes. Pediatric Diabetes. https://doi.org/10.1111/pedi.12893

Epicardial adipose thickness in youth with type 1 diabetes. / Chambers, Melissa A.; Shaibi, Gabriel; Kapadia, Chirag R.; Vander Wyst, Kiley B.; Campos, Amanda; Pimentel, Janiel; Gonsalves, Robert F.; Sandweiss, Bryan M.; Olson, Micah L.

In: Pediatric Diabetes, 01.01.2019.

Research output: Contribution to journalArticle

Chambers, MA, Shaibi, G, Kapadia, CR, Vander Wyst, KB, Campos, A, Pimentel, J, Gonsalves, RF, Sandweiss, BM & Olson, ML 2019, 'Epicardial adipose thickness in youth with type 1 diabetes', Pediatric Diabetes. https://doi.org/10.1111/pedi.12893
Chambers MA, Shaibi G, Kapadia CR, Vander Wyst KB, Campos A, Pimentel J et al. Epicardial adipose thickness in youth with type 1 diabetes. Pediatric Diabetes. 2019 Jan 1. https://doi.org/10.1111/pedi.12893
Chambers, Melissa A. ; Shaibi, Gabriel ; Kapadia, Chirag R. ; Vander Wyst, Kiley B. ; Campos, Amanda ; Pimentel, Janiel ; Gonsalves, Robert F. ; Sandweiss, Bryan M. ; Olson, Micah L. / Epicardial adipose thickness in youth with type 1 diabetes. In: Pediatric Diabetes. 2019.
@article{85a6562d7b824ba3bd2f98d8a1c2cd3d,
title = "Epicardial adipose thickness in youth with type 1 diabetes",
abstract = "Background and Objective: Epicardial adipose thickness (EAT) is increased in adults with type 1 diabetes (T1D) and is thought to contribute to cardiovascular disease (CVD) in this population. Given that CVD risk factors emerge early in life, the purpose of this study was to identify whether EAT is increased in pediatric patients with T1D compared with non-diabetic controls. Methods: Anthropometric data, blood pressure (BP), and EAT were evaluated in 20 youth with T1D and 20 age, sex, and body mass index (BMI) matched healthy controls between the ages of 5 and 18 years. Results: EAT was 18.5{\%} higher among youth with T1D compared to healthy controls (1.65 ± 0.44 mm vs 1.37 ± 0.27 mm, P =.02). In the entire cohort, EAT was correlated with age (r = 0.71, P <.001), BMI (r =.69, P <.001), waist circumference (r = 0.60, P <.001), systolic BP (r =.34, P =.03), and diastolic BP (r = 0.41, P =.009). Among youth with T1D, there were no significant correlations between EAT and HbA1c (r = −0.16, P =.50), insulin dose (r =.09, P =.71), or duration of disease (r = 0.06, P =.82). Conclusions: Youth with T1D exhibited significantly higher EAT compared to controls. Increased EAT was associated with adiposity and BP, but not duration of disease, insulin dose, or glycemic control. Increased EAT may represent a pathophysiologic mechanism leading to premature CVD in pediatric patients with T1D.",
keywords = "adipose tissue, adolescent, cardiovascular diseases, diabetes mellitus, type 1, risk factors",
author = "Chambers, {Melissa A.} and Gabriel Shaibi and Kapadia, {Chirag R.} and {Vander Wyst}, {Kiley B.} and Amanda Campos and Janiel Pimentel and Gonsalves, {Robert F.} and Sandweiss, {Bryan M.} and Olson, {Micah L.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1111/pedi.12893",
language = "English (US)",
journal = "Pediatric Diabetes",
issn = "1399-543X",
publisher = "Blackwell Munksgaard",

}

TY - JOUR

T1 - Epicardial adipose thickness in youth with type 1 diabetes

AU - Chambers, Melissa A.

AU - Shaibi, Gabriel

AU - Kapadia, Chirag R.

AU - Vander Wyst, Kiley B.

AU - Campos, Amanda

AU - Pimentel, Janiel

AU - Gonsalves, Robert F.

AU - Sandweiss, Bryan M.

AU - Olson, Micah L.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background and Objective: Epicardial adipose thickness (EAT) is increased in adults with type 1 diabetes (T1D) and is thought to contribute to cardiovascular disease (CVD) in this population. Given that CVD risk factors emerge early in life, the purpose of this study was to identify whether EAT is increased in pediatric patients with T1D compared with non-diabetic controls. Methods: Anthropometric data, blood pressure (BP), and EAT were evaluated in 20 youth with T1D and 20 age, sex, and body mass index (BMI) matched healthy controls between the ages of 5 and 18 years. Results: EAT was 18.5% higher among youth with T1D compared to healthy controls (1.65 ± 0.44 mm vs 1.37 ± 0.27 mm, P =.02). In the entire cohort, EAT was correlated with age (r = 0.71, P <.001), BMI (r =.69, P <.001), waist circumference (r = 0.60, P <.001), systolic BP (r =.34, P =.03), and diastolic BP (r = 0.41, P =.009). Among youth with T1D, there were no significant correlations between EAT and HbA1c (r = −0.16, P =.50), insulin dose (r =.09, P =.71), or duration of disease (r = 0.06, P =.82). Conclusions: Youth with T1D exhibited significantly higher EAT compared to controls. Increased EAT was associated with adiposity and BP, but not duration of disease, insulin dose, or glycemic control. Increased EAT may represent a pathophysiologic mechanism leading to premature CVD in pediatric patients with T1D.

AB - Background and Objective: Epicardial adipose thickness (EAT) is increased in adults with type 1 diabetes (T1D) and is thought to contribute to cardiovascular disease (CVD) in this population. Given that CVD risk factors emerge early in life, the purpose of this study was to identify whether EAT is increased in pediatric patients with T1D compared with non-diabetic controls. Methods: Anthropometric data, blood pressure (BP), and EAT were evaluated in 20 youth with T1D and 20 age, sex, and body mass index (BMI) matched healthy controls between the ages of 5 and 18 years. Results: EAT was 18.5% higher among youth with T1D compared to healthy controls (1.65 ± 0.44 mm vs 1.37 ± 0.27 mm, P =.02). In the entire cohort, EAT was correlated with age (r = 0.71, P <.001), BMI (r =.69, P <.001), waist circumference (r = 0.60, P <.001), systolic BP (r =.34, P =.03), and diastolic BP (r = 0.41, P =.009). Among youth with T1D, there were no significant correlations between EAT and HbA1c (r = −0.16, P =.50), insulin dose (r =.09, P =.71), or duration of disease (r = 0.06, P =.82). Conclusions: Youth with T1D exhibited significantly higher EAT compared to controls. Increased EAT was associated with adiposity and BP, but not duration of disease, insulin dose, or glycemic control. Increased EAT may represent a pathophysiologic mechanism leading to premature CVD in pediatric patients with T1D.

KW - adipose tissue

KW - adolescent

KW - cardiovascular diseases

KW - diabetes mellitus, type 1

KW - risk factors

UR - http://www.scopus.com/inward/record.url?scp=85069881546&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85069881546&partnerID=8YFLogxK

U2 - 10.1111/pedi.12893

DO - 10.1111/pedi.12893

M3 - Article

C2 - 31294894

AN - SCOPUS:85069881546

JO - Pediatric Diabetes

JF - Pediatric Diabetes

SN - 1399-543X

ER -