Enzymatic detection of traumatic brain injury related biomarkers

Brittney A. Cardinell, Jeffrey LaBelle

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Electrochemical detection methods have been popular in the medical diagnostics field. Several well-known devices such as the self-monitoring blood glucose meter have relied on electrochemical techniques for their sensitivity, and ability to make direct measurements without optical labels. Currently, no point-of-care or handheld diagnostic tool exists to quantify the severity of a traumatic brain injury (TBI). We have shown that enzymatic detection of norepinephrine (NE), a biomarker which can indicate TBI severity, using impedance-based electrochemical techniques can achieve the required sensitivity, ~100 pg/mL. Furthermore, the first steps have been taken to quantify NE in whole blood solutions and to optimize the technique for a handheld device.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages89-112
Number of pages24
DOIs
StatePublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1572
ISSN (Print)1064-3745

Keywords

  • Biomarker
  • Biosensor
  • Electrochemical impedance spectroscopy
  • Enzyme
  • Impedance time
  • Norepinephrine
  • Point-of-care technology
  • Traumatic brain injury

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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