@inbook{cb1ad9899cab456eb20327cfd3e5b57f,
title = "Enzymatic detection of traumatic brain injury related biomarkers",
abstract = "Electrochemical detection methods have been popular in the medical diagnostics field. Several well-known devices such as the self-monitoring blood glucose meter have relied on electrochemical techniques for their sensitivity, and ability to make direct measurements without optical labels. Currently, no point-of-care or handheld diagnostic tool exists to quantify the severity of a traumatic brain injury (TBI). We have shown that enzymatic detection of norepinephrine (NE), a biomarker which can indicate TBI severity, using impedance-based electrochemical techniques can achieve the required sensitivity, ~100 pg/mL. Furthermore, the first steps have been taken to quantify NE in whole blood solutions and to optimize the technique for a handheld device.",
keywords = "Biomarker, Biosensor, Electrochemical impedance spectroscopy, Enzyme, Impedance time, Norepinephrine, Point-of-care technology, Traumatic brain injury",
author = "Cardinell, {Brittney A.} and Jeffrey LaBelle",
note = "Funding Information: This research is sponsored by the School of Biological Health and Systems Engineering at Arizona State University. Thanks to Carissa Henriksen and David Probst for their help in obtaining the photograph in Fig. 1. Publisher Copyright: {\textcopyright} Springer Science+Business Media LLC 2017.",
year = "2017",
doi = "10.1007/978-1-4939-6911-1_7",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "89--112",
booktitle = "Methods in Molecular Biology",
}