Enzymatic cleavage of RNA by RNA

Sidney Altman, Madeline Baer, Cecilia Guerrier-Takada, Agustin Vioque

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


The catalytic activity of E. coli RNase P, an enzyme essential for tRNA biosynthesis in vivo, resides in the RNA subunit of the enzyme. This RNA, which has all the properties of a classical enzyme, can cleave precursor tRNAs in vitro in the total absence of proteins.

Original languageEnglish (US)
Pages (from-to)515-518
Number of pages4
JournalTrends in Biochemical Sciences
Issue number12
StatePublished - Dec 1986
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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