Environmental control programs the emergence of distinct functional ensembles from unconstrained chemical reactions

Andrew J. Surman, Marc Rodriguez-Garcia, Yousef M. Abul-Haija, Geoffrey J.T. Cooper, Piotr S. Gromski, Rebecca Turk-MacLeoda, Margaret Mullin, Cole Mathis, Sara Walker, Leroy Cronin

    Research output: Contribution to journalArticle

    Abstract

    Many approaches to the origin of life focus on how the molecules found in biology might be made in the absence of biological processes, from the simplest plausible starting materials. Another approach could be to view the emergence of the chemistry of biology as process whereby the environment effectively directs “primordial soups” toward structure, function, and genetic systems over time. This does not require the molecules found in biology today to be made initially, and leads to the hypothesis that environment can direct chemical soups toward order, and eventually living systems. Herein, we show how unconstrained condensation reactions can be steered by changes in the reaction environment, such as order of reactant addition, and addition of salts or minerals. Using omics techniques to survey the resulting chemical ensembles we demonstrate there are distinct, significant, and reproducible differences between the product mixtures. Furthermore, we observe that these differences in composition have consequences, manifested in clearly different structural and functional properties. We demonstrate that simple variations in environmental parameters lead to differentiation of distinct chemical ensembles from both amino acid mixtures and a primordial soup model. We show that the synthetic complexity emerging from such unconstrained reactions is not as intractable as often suggested, when viewed through a chemically agnostic lens. An open approach to complexity can generate compositional, structural, and functional diversity from fixed sets of simple starting materials, suggesting that differentiation of chemical ensembles can occur in the wider environment without the need for biological machinery.

    Original languageEnglish (US)
    Pages (from-to)5387-5392
    Number of pages6
    JournalProceedings of the National Academy of Sciences of the United States of America
    Volume116
    Issue number12
    DOIs
    StatePublished - Jan 1 2019

    Fingerprint

    Biological Phenomena
    Genetic Structures
    Lenses
    Minerals
    Salts
    Amino Acids
    Surveys and Questionnaires
    Origin of Life

    Keywords

    • Chemomics
    • Combinatorial chemistry
    • Origin of life
    • Peptides
    • Systems chemistry

    ASJC Scopus subject areas

    • General

    Cite this

    Surman, A. J., Rodriguez-Garcia, M., Abul-Haija, Y. M., Cooper, G. J. T., Gromski, P. S., Turk-MacLeoda, R., ... Cronin, L. (2019). Environmental control programs the emergence of distinct functional ensembles from unconstrained chemical reactions. Proceedings of the National Academy of Sciences of the United States of America, 116(12), 5387-5392. https://doi.org/10.1073/pnas.1813987116

    Environmental control programs the emergence of distinct functional ensembles from unconstrained chemical reactions. / Surman, Andrew J.; Rodriguez-Garcia, Marc; Abul-Haija, Yousef M.; Cooper, Geoffrey J.T.; Gromski, Piotr S.; Turk-MacLeoda, Rebecca; Mullin, Margaret; Mathis, Cole; Walker, Sara; Cronin, Leroy.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, No. 12, 01.01.2019, p. 5387-5392.

    Research output: Contribution to journalArticle

    Surman, AJ, Rodriguez-Garcia, M, Abul-Haija, YM, Cooper, GJT, Gromski, PS, Turk-MacLeoda, R, Mullin, M, Mathis, C, Walker, S & Cronin, L 2019, 'Environmental control programs the emergence of distinct functional ensembles from unconstrained chemical reactions' Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 12, pp. 5387-5392. https://doi.org/10.1073/pnas.1813987116
    Surman, Andrew J. ; Rodriguez-Garcia, Marc ; Abul-Haija, Yousef M. ; Cooper, Geoffrey J.T. ; Gromski, Piotr S. ; Turk-MacLeoda, Rebecca ; Mullin, Margaret ; Mathis, Cole ; Walker, Sara ; Cronin, Leroy. / Environmental control programs the emergence of distinct functional ensembles from unconstrained chemical reactions. In: Proceedings of the National Academy of Sciences of the United States of America. 2019 ; Vol. 116, No. 12. pp. 5387-5392.
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