Enhanced transmission of drug-resistant parasites to mosquitoes following drug treatment in rodent malaria

Andrew S. Bell, Silvie Huijben, Krijn Paaijmans, Derek G. Sim, Brian H.K. Chan, William A. Nelson, Andrew F. Read

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The evolution of drug resistant Plasmodium parasites is a major challenge to effective malaria control. In theory, competitive interactions between sensitive parasites and resistant parasites within infections are a major determinant of the rate at which parasite evolution undermines drug efficacy. Competitive suppression of resistant parasites in untreated hosts slows the spread of resistance; competitive release following treatment enhances it. Here we report that for the murine model Plasmodium chabaudi, co-infection with drug-sensitive parasites can prevent the transmission of initially rare resistant parasites to mosquitoes. Removal of drug-sensitive parasites following chemotherapy enabled resistant parasites to transmit to mosquitoes as successfully as sensitive parasites in the absence of treatment. We also show that the genetic composition of gametocyte populations in host venous blood accurately reflects the genetic composition of gametocytes taken up by mosquitoes. Our data demonstrate that, at least for this mouse model, aggressive chemotherapy leads to very effective transmission of highly resistant parasites that are present in an infection, the very parasites which undermine the long term efficacy of front-line drugs.

Original languageEnglish (US)
Article numbere37172
JournalPLoS One
Volume7
Issue number6
DOIs
StatePublished - Jun 6 2012
Externally publishedYes

Fingerprint

Drug therapy
Culicidae
malaria
Malaria
drug therapy
Rodentia
Parasites
rodents
parasites
drugs
Pharmaceutical Preparations
Therapeutics
Parasitic Diseases
gametocytes
Chemotherapy
Plasmodium chabaudi
Malaria control
Drug Therapy
animal models
Plasmodium

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Enhanced transmission of drug-resistant parasites to mosquitoes following drug treatment in rodent malaria. / Bell, Andrew S.; Huijben, Silvie; Paaijmans, Krijn; Sim, Derek G.; Chan, Brian H.K.; Nelson, William A.; Read, Andrew F.

In: PLoS One, Vol. 7, No. 6, e37172, 06.06.2012.

Research output: Contribution to journalArticle

Bell, Andrew S. ; Huijben, Silvie ; Paaijmans, Krijn ; Sim, Derek G. ; Chan, Brian H.K. ; Nelson, William A. ; Read, Andrew F. / Enhanced transmission of drug-resistant parasites to mosquitoes following drug treatment in rodent malaria. In: PLoS One. 2012 ; Vol. 7, No. 6.
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