Engineering transport systems for microbial production

Moses Onyeabor, Rodrigo Martinez, Gavin Kurgan, Xuan Wang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The rapid development in the field of metabolic engineering has enabled complex modifications of metabolic pathways to generate a diverse product portfolio. Manipulating substrate uptake and product export is an important research area in metabolic engineering. Optimization of transport systems has the potential to enhance microbial production of renewable fuels and chemicals. This chapter comprehensively reviews the transport systems critical for microbial production as well as current genetic engineering strategies to improve transport functions and thus production metrics. In addition, this chapter highlights recent advancements in engineering microbial efflux systems to enhance cellular tolerance to industrially relevant chemical stress. Lastly, future directions to address current technological gaps are discussed.

Original languageEnglish (US)
Title of host publicationAdvances in Applied Microbiology
PublisherAcademic Press Inc
Pages33-87
Number of pages55
DOIs
StatePublished - 2020

Publication series

NameAdvances in Applied Microbiology
Volume111
ISSN (Print)0065-2164

Keywords

  • Efflux pumps
  • Metabolic engineering
  • Microbial production
  • Product export
  • Transporters

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology

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  • Cite this

    Onyeabor, M., Martinez, R., Kurgan, G., & Wang, X. (2020). Engineering transport systems for microbial production. In Advances in Applied Microbiology (pp. 33-87). (Advances in Applied Microbiology; Vol. 111). Academic Press Inc. https://doi.org/10.1016/bs.aambs.2020.01.002