Engineering bacterial sugar catabolism and tolerance toward lignocellulose conversion

Andrew D. Flores, Gavin L. Kurgan, Xuan Wang

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Lignocellulosic biomass represents a renewable domestic feedstock that can support large-scale biochemical production processes for fuels and specialty chemicals. However, cost-effective conversion of lignocellulosic sugars into valuable chemicals still remains a challenge. Biomass recalcitrance to saccharification, microbial sugar co-utilization and toxic chemicals associated with chemical pretreatments are at the center of the bottlenecks limiting further commercialization of lignocellulose conversion. Genetic and metabolic engineering has allowed researchers to manipulate microorganisms to overcome these challenges. In this chapter, a broad overview of the current knowledge and research efforts in two paramount areas is presented: (1) bacterial carbon catabolite repression and sugar co-utilization, and (2) microbial tolerance to inhibitors derived from lignocellulose pretreatments. Lastly, technological gaps and future directions for further improvements are discussed. This chapter will mainly focus on the relevant knowledge and research progress from the perspective of bacterial strain engineering.

    Original languageEnglish (US)
    Title of host publicationEngineering of Microorganisms for the Production of Chemicals and Biofuels from Renewable Resources
    PublisherSpringer International Publishing
    Pages147-180
    Number of pages34
    ISBN (Electronic)9783319517292
    ISBN (Print)9783319517285
    DOIs
    StatePublished - Jan 1 2017

    Fingerprint

    Sugars
    Biomass
    Biochemical Phenomena
    Catabolite Repression
    Metabolic Engineering
    Genetic Engineering
    Poisons
    Research
    Research Personnel
    Metabolic engineering
    Costs and Cost Analysis
    Genetic engineering
    Saccharification
    Microorganisms
    Feedstocks
    Carbon
    lignocellulose
    Costs
    Direction compound

    Keywords

    • Alternative feedstock
    • Carbon catabolite repression
    • Furan aldehydes
    • Lignocellulose conversion
    • Metabolic engineering
    • Sugar catabolism

    ASJC Scopus subject areas

    • Medicine(all)
    • Health Professions(all)
    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Flores, A. D., Kurgan, G. L., & Wang, X. (2017). Engineering bacterial sugar catabolism and tolerance toward lignocellulose conversion. In Engineering of Microorganisms for the Production of Chemicals and Biofuels from Renewable Resources (pp. 147-180). Springer International Publishing. https://doi.org/10.1007/978-3-319-51729-2_6

    Engineering bacterial sugar catabolism and tolerance toward lignocellulose conversion. / Flores, Andrew D.; Kurgan, Gavin L.; Wang, Xuan.

    Engineering of Microorganisms for the Production of Chemicals and Biofuels from Renewable Resources. Springer International Publishing, 2017. p. 147-180.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Flores, AD, Kurgan, GL & Wang, X 2017, Engineering bacterial sugar catabolism and tolerance toward lignocellulose conversion. in Engineering of Microorganisms for the Production of Chemicals and Biofuels from Renewable Resources. Springer International Publishing, pp. 147-180. https://doi.org/10.1007/978-3-319-51729-2_6
    Flores AD, Kurgan GL, Wang X. Engineering bacterial sugar catabolism and tolerance toward lignocellulose conversion. In Engineering of Microorganisms for the Production of Chemicals and Biofuels from Renewable Resources. Springer International Publishing. 2017. p. 147-180 https://doi.org/10.1007/978-3-319-51729-2_6
    Flores, Andrew D. ; Kurgan, Gavin L. ; Wang, Xuan. / Engineering bacterial sugar catabolism and tolerance toward lignocellulose conversion. Engineering of Microorganisms for the Production of Chemicals and Biofuels from Renewable Resources. Springer International Publishing, 2017. pp. 147-180
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