Engineering artificial niches for regenerative medicine

Jessica D. Weaver, Andrés J. García

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

An emerging area of regenerative medicine is the engineering of artificial extracellular matrices that recapitulate biochemical and biophysical characteristics of native tissue environments to create an instructive microenvironment through a variety of biomaterials-based approaches. Key components of an artificial niche comprise a combination of biophysical, biochemical, and intercellular signaling. This microenvironment can be used for in vitro studies or to recapitulate an in vivo setting, to study cellular processes in a controlled manner or replace tissue. This article outlines details on fundamental and state of the art strategies in engineering artificial niches for regenerative medicine applications.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Tissue Engineering and Regenerative Medicine
PublisherElsevier
Pages103-108
Number of pages6
Volume1-3
ISBN (Electronic)9780128136997
ISBN (Print)9780128137000
DOIs
StatePublished - Jan 1 2019

Keywords

  • Artificial niche
  • Biochemical cues
  • Biomaterials
  • Biophysical cues
  • Cellular interactions
  • Matrices
  • Microenvironment
  • Regenerative medicine
  • Tissue engineering
  • Topographical features

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Weaver, J. D., & García, A. J. (2019). Engineering artificial niches for regenerative medicine. In Encyclopedia of Tissue Engineering and Regenerative Medicine (Vol. 1-3, pp. 103-108). Elsevier. https://doi.org/10.1016/B978-0-12-801238-3.11128-6