Energetic clues to pathways to biomineralization: Precursors, clusters, and nanoparticles

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373 Scopus citations

Abstract

Nanoparticle and nanocluster precursors may play a major role in biomineralization. The small differences in enthalpy and free energy among metastable nanoscale phases offer controlled thermodynamic and mechanistic pathways. Clusters and nanoparticles offer concentration and controlled transport of reactants. Control of polymorphism, surface energy, and surface charge on nanoparticles can lead to morphological control and appropriate growth rates of biominerals. Rather than conventional nucleation and growth, assembly of nanoparticles may provide alternative mechanisms for crystal growth. The Ostwald step rule, based on a thermodynamic view of nucleation and growth, is supported by the observation that more metastable phases tend to have lower surface energies. Examples from nonbiological systems, stressing the interplay of thermodynamic and kinetic factors, illustrate features potentially important to biomineralization.

Original languageEnglish (US)
Pages (from-to)12096-12101
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume101
Issue number33
DOIs
StatePublished - Aug 17 2004
Externally publishedYes

ASJC Scopus subject areas

  • General

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