Endoscopic system for simultaneous visual examination and electronic detection of fluorescence

J. H. Kinsey; D. A. Cortese

doi:10.1063/1.1136099

Endoscopic system for simultaneous visual examination and electronic detection of fluorescence

J. H. Kinsey, D. A. Cortese

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30 Scopus citations

Abstract

A sensitive parallel system for visual examination of a target area with simultaneous detection and measurement of fluorescent emission from the same region is described. This device, originally designed and constructed for bronchial cancer detection, alternates visual illumination and narrow band excitation radiation in conjunction with a synchronously shuttered PMT at frequencies above the visual flicker fusion threshold to provide parallel operation. The signal from the PMT is synchronously amplified using a lock-in amplifier, the dc output of which is voltage-to-frequency converted and amplified to provide an audible tone whose frequency is proportional to the fluorescence sensed.

Original language	English (US)
Pages (from-to)	1403-1406
Number of pages	4
Journal	Review of Scientific Instruments
Volume	51
Issue number	10
DOIs	https://doi.org/10.1063/1.1136099
State	Published - 1980
Externally published	Yes

ASJC Scopus subject areas

Instrumentation

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10.1063/1.1136099

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title = "Endoscopic system for simultaneous visual examination and electronic detection of fluorescence",

abstract = "A sensitive parallel system for visual examination of a target area with simultaneous detection and measurement of fluorescent emission from the same region is described. This device, originally designed and constructed for bronchial cancer detection, alternates visual illumination and narrow band excitation radiation in conjunction with a synchronously shuttered PMT at frequencies above the visual flicker fusion threshold to provide parallel operation. The signal from the PMT is synchronously amplified using a lock-in amplifier, the dc output of which is voltage-to-frequency converted and amplified to provide an audible tone whose frequency is proportional to the fluorescence sensed.",

author = "Kinsey, {J. H.} and Cortese, {D. A.}",

year = "1980",

doi = "10.1063/1.1136099",

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AU - Kinsey, J. H.

AU - Cortese, D. A.

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N2 - A sensitive parallel system for visual examination of a target area with simultaneous detection and measurement of fluorescent emission from the same region is described. This device, originally designed and constructed for bronchial cancer detection, alternates visual illumination and narrow band excitation radiation in conjunction with a synchronously shuttered PMT at frequencies above the visual flicker fusion threshold to provide parallel operation. The signal from the PMT is synchronously amplified using a lock-in amplifier, the dc output of which is voltage-to-frequency converted and amplified to provide an audible tone whose frequency is proportional to the fluorescence sensed.

AB - A sensitive parallel system for visual examination of a target area with simultaneous detection and measurement of fluorescent emission from the same region is described. This device, originally designed and constructed for bronchial cancer detection, alternates visual illumination and narrow band excitation radiation in conjunction with a synchronously shuttered PMT at frequencies above the visual flicker fusion threshold to provide parallel operation. The signal from the PMT is synchronously amplified using a lock-in amplifier, the dc output of which is voltage-to-frequency converted and amplified to provide an audible tone whose frequency is proportional to the fluorescence sensed.

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Endoscopic system for simultaneous visual examination and electronic detection of fluorescence

Abstract

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