Endogenous Repair Signaling after Brain Injury and Complementary Bioengineering Approaches to Enhance Neural Regeneration: Supplementary Issue: Stem Cell Biology

Caroline P. Addington, Adam Roussas, Dipankar Dutta, Sarah Stabenfeldt

Research output: Contribution to journalReview article

Abstract

Traumatic brain injury (TBI) affects 5.3 million Americans annually. Despite the many long-term deficits associated with TBI, there currently are no clinically available therapies that directly address the underlying pathologies contributing to these deficits. Preclinical studies have investigated various therapeutic approaches for TBI: two such approaches are stem cell transplantation and delivery of bioactive factors to mitigate the biochemical insult affiliated with TBI. However, success with either of these approaches has been limited largely due to the complexity of the injury microenvironment. As such, this review outlines the many factors of the injury microenvironment that mediate endogenous neural regeneration after TBI and the corresponding bioengineering approaches that harness these inherent signaling mechanisms to further amplify regenerative efforts.

Original languageEnglish (US)
Pages (from-to)43-60
Number of pages18
JournalBiomarker Insights
Volume10s1
DOIs
StatePublished - Jan 1 2015

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Cytology
Bioengineering
Stem cells
Brain Injuries
Cell Biology
Regeneration
Brain
Repair
Stem Cells
Wounds and Injuries
Stem Cell Transplantation
Pathology
Traumatic Brain Injury
Therapeutics

Keywords

  • controlled release
  • stem cells
  • transplantation
  • traumatic brain injury

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Biochemistry, medical

Cite this

Endogenous Repair Signaling after Brain Injury and Complementary Bioengineering Approaches to Enhance Neural Regeneration : Supplementary Issue: Stem Cell Biology. / Addington, Caroline P.; Roussas, Adam; Dutta, Dipankar; Stabenfeldt, Sarah.

In: Biomarker Insights, Vol. 10s1, 01.01.2015, p. 43-60.

Research output: Contribution to journalReview article

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