Endogenous Repair Signaling after Brain Injury and Complementary Bioengineering Approaches to Enhance Neural Regeneration: Supplementary Issue: Stem Cell Biology

Caroline P. Addington, Adam Roussas, Dipankar Dutta, Sarah Stabenfeldt

Research output: Contribution to journalReview article

Abstract

Traumatic brain injury (TBI) affects 5.3 million Americans annually. Despite the many long-term deficits associated with TBI, there currently are no clinically available therapies that directly address the underlying pathologies contributing to these deficits. Preclinical studies have investigated various therapeutic approaches for TBI: two such approaches are stem cell transplantation and delivery of bioactive factors to mitigate the biochemical insult affiliated with TBI. However, success with either of these approaches has been limited largely due to the complexity of the injury microenvironment. As such, this review outlines the many factors of the injury microenvironment that mediate endogenous neural regeneration after TBI and the corresponding bioengineering approaches that harness these inherent signaling mechanisms to further amplify regenerative efforts.

Original languageEnglish (US)
Pages (from-to)43-60
Number of pages18
JournalBiomarker Insights
Volume10s1
DOIs
StatePublished - Jan 1 2015

Keywords

  • controlled release
  • stem cells
  • transplantation
  • traumatic brain injury

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'Endogenous Repair Signaling after Brain Injury and Complementary Bioengineering Approaches to Enhance Neural Regeneration: Supplementary Issue: Stem Cell Biology'. Together they form a unique fingerprint.

  • Cite this