Encoding of a homolog of the IFN-γ receptor by myxoma virus

Chris Upton, Karen Mossman, Douglas McFadden

Research output: Contribution to journalArticle

261 Citations (Scopus)

Abstract

Many poxvirus-encoded virulence factors have been identified as proteins that are secreted from infected cells. The major secreted protein (37 kilodaltons) from cells infected with myxoma virus is encoded by the M-T7 open reading frame. This protein has significant sequence similarity to the human and mouse receptors for interferon-gamma (IFN-γ). Furthermore, the myxoma M-T7 protein specifically binds rabbit IFN-γ and inhibits the biological activity of extracellular IFN-γ, one of the key regulatory cytokines in the host immune response against viral infections.

Original languageEnglish (US)
Pages (from-to)1369-1372
Number of pages4
JournalScience
Volume258
Issue number5086
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

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Myxoma virus
Interferon-gamma
Proteins
Poxviridae
Myxoma
Virulence Factors
Virus Diseases
Open Reading Frames
Cytokines
Rabbits
interferon gamma receptor

ASJC Scopus subject areas

  • General

Cite this

Encoding of a homolog of the IFN-γ receptor by myxoma virus. / Upton, Chris; Mossman, Karen; McFadden, Douglas.

In: Science, Vol. 258, No. 5086, 01.01.1992, p. 1369-1372.

Research output: Contribution to journalArticle

Upton, Chris ; Mossman, Karen ; McFadden, Douglas. / Encoding of a homolog of the IFN-γ receptor by myxoma virus. In: Science. 1992 ; Vol. 258, No. 5086. pp. 1369-1372.
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