Encoding of a homolog of the IFN-γ receptor by myxoma virus

Chris Upton, Karen Mossman, Grant McFadden

Research output: Contribution to journalArticle

267 Scopus citations

Abstract

Many poxvirus-encoded virulence factors have been identified as proteins that are secreted from infected cells. The major secreted protein (37 kilodaltons) from cells infected with myxoma virus is encoded by the M-T7 open reading frame. This protein has significant sequence similarity to the human and mouse receptors for interferon-gamma (IFN-γ). Furthermore, the myxoma M-T7 protein specifically binds rabbit IFN-γ and inhibits the biological activity of extracellular IFN-γ, one of the key regulatory cytokines in the host immune response against viral infections.

Original languageEnglish (US)
Pages (from-to)1369-1372
Number of pages4
JournalScience
Volume258
Issue number5086
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

ASJC Scopus subject areas

  • General

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