Encoding of a homolog of the IFN-γ receptor by myxoma virus

Chris Upton; Karen Mossman; Grant McFadden

doi:10.1126/science.1455233

Encoding of a homolog of the IFN-γ receptor by myxoma virus

Chris Upton, Karen Mossman, Grant McFadden

Research output: Contribution to journal › Article › peer-review

278 Scopus citations

Abstract

Many poxvirus-encoded virulence factors have been identified as proteins that are secreted from infected cells. The major secreted protein (37 kilodaltons) from cells infected with myxoma virus is encoded by the M-T7 open reading frame. This protein has significant sequence similarity to the human and mouse receptors for interferon-gamma (IFN-γ). Furthermore, the myxoma M-T7 protein specifically binds rabbit IFN-γ and inhibits the biological activity of extracellular IFN-γ, one of the key regulatory cytokines in the host immune response against viral infections.

Original language	English (US)
Pages (from-to)	1369-1372
Number of pages	4
Journal	Science
Volume	258
Issue number	5086
DOIs	https://doi.org/10.1126/science.1455233
State	Published - 1992
Externally published	Yes

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title = "Encoding of a homolog of the IFN-γ receptor by myxoma virus",

abstract = "Many poxvirus-encoded virulence factors have been identified as proteins that are secreted from infected cells. The major secreted protein (37 kilodaltons) from cells infected with myxoma virus is encoded by the M-T7 open reading frame. This protein has significant sequence similarity to the human and mouse receptors for interferon-gamma (IFN-γ). Furthermore, the myxoma M-T7 protein specifically binds rabbit IFN-γ and inhibits the biological activity of extracellular IFN-γ, one of the key regulatory cytokines in the host immune response against viral infections.",

author = "Chris Upton and Karen Mossman and Grant McFadden",

year = "1992",

doi = "10.1126/science.1455233",

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AU - Upton, Chris

AU - Mossman, Karen

AU - McFadden, Grant

PY - 1992

Y1 - 1992

N2 - Many poxvirus-encoded virulence factors have been identified as proteins that are secreted from infected cells. The major secreted protein (37 kilodaltons) from cells infected with myxoma virus is encoded by the M-T7 open reading frame. This protein has significant sequence similarity to the human and mouse receptors for interferon-gamma (IFN-γ). Furthermore, the myxoma M-T7 protein specifically binds rabbit IFN-γ and inhibits the biological activity of extracellular IFN-γ, one of the key regulatory cytokines in the host immune response against viral infections.

AB - Many poxvirus-encoded virulence factors have been identified as proteins that are secreted from infected cells. The major secreted protein (37 kilodaltons) from cells infected with myxoma virus is encoded by the M-T7 open reading frame. This protein has significant sequence similarity to the human and mouse receptors for interferon-gamma (IFN-γ). Furthermore, the myxoma M-T7 protein specifically binds rabbit IFN-γ and inhibits the biological activity of extracellular IFN-γ, one of the key regulatory cytokines in the host immune response against viral infections.

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Encoding of a homolog of the IFN-γ receptor by myxoma virus

Abstract

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