Abstract
Many poxvirus-encoded virulence factors have been identified as proteins that are secreted from infected cells. The major secreted protein (37 kilodaltons) from cells infected with myxoma virus is encoded by the M-T7 open reading frame. This protein has significant sequence similarity to the human and mouse receptors for interferon-gamma (IFN-γ). Furthermore, the myxoma M-T7 protein specifically binds rabbit IFN-γ and inhibits the biological activity of extracellular IFN-γ, one of the key regulatory cytokines in the host immune response against viral infections.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1369-1372 |
| Number of pages | 4 |
| Journal | Science |
| Volume | 258 |
| Issue number | 5086 |
| State | Published - Nov 20 1992 |
| Externally published | Yes |
ASJC Scopus subject areas
- General