Enabling Precision Cardiology Through Multiscale Biology and Systems Medicine

Kipp W. Johnson, Khader Shameer, Benjamin S. Glicksberg, Ben Readhead, Partho P. Sengupta, Johan L.M. Björkegren, Jason C. Kovacic, Joel T. Dudley

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

The traditional paradigm of cardiovascular disease research derives insight from large-scale, broadly inclusive clinical studies of well-characterized pathologies. These insights are then put into practice according to standardized clinical guidelines. However, stagnation in the development of new cardiovascular therapies and variability in therapeutic response implies that this paradigm is insufficient for reducing the cardiovascular disease burden. In this state-of-the-art review, we examine 3 interconnected ideas we put forth as key concepts for enabling a transition to precision cardiology: 1) precision characterization of cardiovascular disease with machine learning methods; 2) the application of network models of disease to embrace disease complexity; and 3) using insights from the previous 2 ideas to enable pharmacology and polypharmacology systems for more precise drug-to-patient matching and patient-disease stratification. We conclude by exploring the challenges of applying a precision approach to cardiology, which arise from a deficit of the required resources and infrastructure, and emerging evidence for the clinical effectiveness of this nascent approach.

Original languageEnglish (US)
Pages (from-to)311-327
Number of pages17
JournalJACC: Basic to Translational Science
Volume2
Issue number3
DOIs
StatePublished - Jun 2017

Keywords

  • cardiology
  • clinical informatics
  • multi-omics
  • precision medicine
  • translational bioinformatics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Johnson, K. W., Shameer, K., Glicksberg, B. S., Readhead, B., Sengupta, P. P., Björkegren, J. L. M., Kovacic, J. C., & Dudley, J. T. (2017). Enabling Precision Cardiology Through Multiscale Biology and Systems Medicine. JACC: Basic to Translational Science, 2(3), 311-327. https://doi.org/10.1016/j.jacbts.2016.11.010