An investigation of the Caregiver Autism Residential E-health (CARE) system, a low-cost, end-user deployable smart home technology, has been evaluated for its potential as an empowering assistive technology for adults living with autism. It allows adults living with autism and their caregivers to create personalized smart home interventions that provide motivational support for activities of daily living, social relationships, and safer behaviors. This is achieved through the use of a ubiquitous computing system composed of off-the-shelf consumer electronic technologies. The Environmental Rating Scale (ERS), designed to assess residential interventions for people living with autism, guided the development and evaluation of CARE/ERS heuristics and interaction scenarios. The contributions of this investigation, advanced through an iterative design process involving expert reviewers, caregivers, and end-users in a patient centered approach for the design of actualizing e-health interventions, can be readily applied to a broad range of residential circumstances that improve quality of life.