Empirical modeling of metabolic alkalosis induced by sodium bicarbonate ingestion

Simon Green, Jason C. Siegler

Research output: Contribution to journalComment/debatepeer-review

1 Scopus citations

Abstract

Biphasic responses of blood HCO3- concentration and H+ concentration following ingestion of 3 doses of NaHCO3 (0.1, 0.2, 0.3 g·kg-1) were assessed in 8 men. For HCO3- concentration, there were significant effects of dose on maximum responses and timing, as well amplitudes, onsets, and/or time constants of phases 1 and 2. Fewer significant effects of dose were observed for H+ concentration and additional data demonstrated differential effects of dose on HCO3- concentration and H+ concentration responses and underlying phases.

Original languageEnglish (US)
Pages (from-to)1092-1095
Number of pages4
JournalApplied Physiology, Nutrition and Metabolism
Volume41
Issue number10
DOIs
StatePublished - 2016
Externally publishedYes

Keywords

  • Alkali
  • Alkalosis
  • Dose
  • Magnitude
  • Parameter estimation
  • Timecourse

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)

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