Empirical modeling of metabolic alkalosis induced by sodium bicarbonate ingestion

Simon Green; Jason C. Siegler

doi:10.1139/apnm-2016-0175

Empirical modeling of metabolic alkalosis induced by sodium bicarbonate ingestion

Simon Green, Jason C. Siegler

Research output: Contribution to journal › Comment/debate › peer-review

2 Scopus citations

Abstract

Biphasic responses of blood HCO₃^- concentration and H+ concentration following ingestion of 3 doses of NaHCO³ (0.1, 0.2, 0.3 g·kg^-1) were assessed in 8 men. For HCO₃^- concentration, there were significant effects of dose on maximum responses and timing, as well amplitudes, onsets, and/or time constants of phases 1 and 2. Fewer significant effects of dose were observed for H+ concentration and additional data demonstrated differential effects of dose on HCO₃^- concentration and H+ concentration responses and underlying phases.

Original language	English (US)
Pages (from-to)	1092-1095
Number of pages	4
Journal	Applied Physiology, Nutrition and Metabolism
Volume	41
Issue number	10
DOIs	https://doi.org/10.1139/apnm-2016-0175
State	Published - 2016
Externally published	Yes

Keywords

Alkali
Alkalosis
Dose
Magnitude
Parameter estimation
Timecourse

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Physiology
Nutrition and Dietetics
Physiology (medical)

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10.1139/apnm-2016-0175

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title = "Empirical modeling of metabolic alkalosis induced by sodium bicarbonate ingestion",

abstract = "Biphasic responses of blood HCO3- concentration and H+ concentration following ingestion of 3 doses of NaHCO3 (0.1, 0.2, 0.3 g·kg-1) were assessed in 8 men. For HCO3- concentration, there were significant effects of dose on maximum responses and timing, as well amplitudes, onsets, and/or time constants of phases 1 and 2. Fewer significant effects of dose were observed for H+ concentration and additional data demonstrated differential effects of dose on HCO3- concentration and H+ concentration responses and underlying phases.",

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T1 - Empirical modeling of metabolic alkalosis induced by sodium bicarbonate ingestion

AU - Green, Simon

AU - Siegler, Jason C.

PY - 2016

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AB - Biphasic responses of blood HCO3- concentration and H+ concentration following ingestion of 3 doses of NaHCO3 (0.1, 0.2, 0.3 g·kg-1) were assessed in 8 men. For HCO3- concentration, there were significant effects of dose on maximum responses and timing, as well amplitudes, onsets, and/or time constants of phases 1 and 2. Fewer significant effects of dose were observed for H+ concentration and additional data demonstrated differential effects of dose on HCO3- concentration and H+ concentration responses and underlying phases.

KW - Alkali

KW - Alkalosis

KW - Dose

KW - Magnitude

KW - Parameter estimation

KW - Timecourse

UR - http://www.scopus.com/inward/record.url?scp=84991102833&partnerID=8YFLogxK

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DO - 10.1139/apnm-2016-0175

M3 - Comment/debate

AN - SCOPUS:84991102833

SN - 1715-5312

VL - 41

SP - 1092

EP - 1095

JO - Applied Physiology, Nutrition and Metabolism

JF - Applied Physiology, Nutrition and Metabolism

IS - 10

ER -

Empirical modeling of metabolic alkalosis induced by sodium bicarbonate ingestion

Abstract

Keywords

ASJC Scopus subject areas

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