Empirical and theoretical models of equilibrium and non-equilibrium transition temperatures of supplemented phase diagrams in aqueous systems (IUPAC technical report)

Horacio R. Corti, Charles Angell, Tony Auffret, Harry Levine, M. Pilar Buera, David S. Reid, Yrjö H. Roos, Louise Slade

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

This paper describes the main thermodynamic concepts related to the construction of supplemented phase (or state) diagrams (SPDs) for aqueous solutions containing vitrifying agents used in the cryo-and dehydro-preservation of natural (foods, seeds, etc.) and synthetic (pharmaceuticals) products. It also reviews the empirical and theoretical equations employed to predict equilibrium transitions (ice freezing, solute solubility) and non-equilibrium transitions (glass transition and the extrapolated freezing curve). The comparison with experimental results is restricted to carbohydrate aqueous solutions, because these are the most widely used cryoprotectant agents. The paper identifies the best standard procedure to determine the glass transition curve over the entire water-content scale, and how to determine the temperature and concentration of the maximally freeze-concentrated solution.

Original languageEnglish (US)
Pages (from-to)1065-1097
Number of pages33
JournalPure and Applied Chemistry
Volume82
Issue number5
DOIs
StatePublished - Jun 14 2010

Keywords

  • Aqueous solutions
  • Carbohydrates
  • Cryoprotectants
  • Freezing point
  • Glass transition
  • IUPAC physical and biophysical chemistry division
  • Maximally freeze-concentrated solution
  • Solubility
  • State phase diagrams

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Fingerprint Dive into the research topics of 'Empirical and theoretical models of equilibrium and non-equilibrium transition temperatures of supplemented phase diagrams in aqueous systems (IUPAC technical report)'. Together they form a unique fingerprint.

  • Cite this