TY - JOUR
T1 - Emerging Biofabrication Strategies for Engineering Complex Tissue Constructs
AU - Pedde, R. Daniel
AU - Mirani, Bahram
AU - Navaei, Ali
AU - Styan, Tara
AU - Wong, Sarah
AU - Mehrali, Mehdi
AU - Thakur, Ashish
AU - Mohtaram, Nima Khadem
AU - Bayati, Armin
AU - Dolatshahi-Pirouz, Alireza
AU - Nikkhah, Mehdi
AU - Willerth, Stephanie M.
AU - Akbari, Mohsen
N1 - Funding Information:
R.D.P. and B.M. contributed equally to this paper. M.A. would like to thank the Natural Sciences and Engineering Research Council of Canada (NSERC) and Canadian Foundation for Innovation for supporting this work. S.M.W. received support from the Canada Research Chairs program, the Stem Cell Network, NSERC, and the International Collaboration on Repair Discoveries. The authors would like to thank Don Pedde for his thorough review of the manuscript—we acknowledge and appreciate his keen eye for detail. This work was supported in part by Health Resources and Services Administration contract 234-2005-37011C. The content is the responsibility of the authors alone and does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.
Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2017/5/17
Y1 - 2017/5/17
N2 - The demand for organ transplantation and repair, coupled with a shortage of available donors, poses an urgent clinical need for the development of innovative treatment strategies for long-term repair and regeneration of injured or diseased tissues and organs. Bioengineering organs, by growing patient-derived cells in biomaterial scaffolds in the presence of pertinent physicochemical signals, provides a promising solution to meet this demand. However, recapitulating the structural and cytoarchitectural complexities of native tissues in vitro remains a significant challenge to be addressed. Through tremendous efforts over the past decade, several innovative biofabrication strategies have been developed to overcome these challenges. This review highlights recent work on emerging three-dimensional bioprinting and textile techniques, compares the advantages and shortcomings of these approaches, outlines the use of common biomaterials and advanced hybrid scaffolds, and describes several design considerations including the structural, physical, biological, and economical parameters that are crucial for the fabrication of functional, complex, engineered tissues. Finally, the applications of these biofabrication strategies in neural, skin, connective, and muscle tissue engineering are explored.
AB - The demand for organ transplantation and repair, coupled with a shortage of available donors, poses an urgent clinical need for the development of innovative treatment strategies for long-term repair and regeneration of injured or diseased tissues and organs. Bioengineering organs, by growing patient-derived cells in biomaterial scaffolds in the presence of pertinent physicochemical signals, provides a promising solution to meet this demand. However, recapitulating the structural and cytoarchitectural complexities of native tissues in vitro remains a significant challenge to be addressed. Through tremendous efforts over the past decade, several innovative biofabrication strategies have been developed to overcome these challenges. This review highlights recent work on emerging three-dimensional bioprinting and textile techniques, compares the advantages and shortcomings of these approaches, outlines the use of common biomaterials and advanced hybrid scaffolds, and describes several design considerations including the structural, physical, biological, and economical parameters that are crucial for the fabrication of functional, complex, engineered tissues. Finally, the applications of these biofabrication strategies in neural, skin, connective, and muscle tissue engineering are explored.
KW - 3D printing
KW - biofabrication
KW - regenerative medicine
KW - textiles
KW - tissue engineering
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U2 - 10.1002/adma.201606061
DO - 10.1002/adma.201606061
M3 - Review article
C2 - 28370405
AN - SCOPUS:85017382452
SN - 0935-9648
VL - 29
JO - Advanced Materials
JF - Advanced Materials
IS - 19
M1 - 1606061
ER -