Emergence of an optimal temperature in action-potential propagation through myelinated axons

Xinlin Song, Hengtong Wang, Yong Chen, Ying Cheng Lai

Research output: Contribution to journalArticle

Abstract

In biological organisms, an optimal temperature exists at which the system functioning is maximized or is most effective. To obtain a general and quantitative understanding of the emergence of the optimal temperature is a challenging task. We aim to gain insights into this significant problem in biological physics by addressing the problem of propagation of action potential in myelinated axons. In particular, we construct a Hodgkin-Huxley type of cortical, compartmental model to describe the nodes of Ranvier with coupling between a pair of neighboring compartments characterized by internodal conductance and investigate the effect of temperature on the propagation of the action potential. We conduct direct numerical simulations and develop a physical analysis by taking advantage of the spatially continuous approximation. We find that increasing the temperature requires a larger value of the critical internodal conductance for successful propagation. The striking finding is the spontaneous emergence of an optimal temperature in the sense that, for the propagation of a single action potential at a fixed value of the internodal conductance, the minimum average passage time for one node of Ranvier occurs at this temperature value. A remarkable phenomenon is that the value of the optimal temperature is similar to those of living biological systems observed in experiments.

Original languageEnglish (US)
Article number032416
JournalPhysical Review E
Volume100
Issue number3
DOIs
StatePublished - Sep 30 2019
Externally publishedYes

Fingerprint

axons
Action Potential
Propagation
propagation
Conductance
temperature
Passage Time
Compartmental Model
Living Systems
compartments
Vertex of a graph
direct numerical simulation
organisms
Biological Systems
Physics
physics
Approximation
approximation

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

Cite this

Emergence of an optimal temperature in action-potential propagation through myelinated axons. / Song, Xinlin; Wang, Hengtong; Chen, Yong; Lai, Ying Cheng.

In: Physical Review E, Vol. 100, No. 3, 032416, 30.09.2019.

Research output: Contribution to journalArticle

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