Embedding of liquids into water soluble materials via additive manufacturing for timed release

Callie Zawaski, Evan Margaretta, Andre Stevenson, Allison Pekkanen, Abby Whittington, Timothy Long, Christopher B. Williams

Research output: Contribution to conferencePaperpeer-review

2 Scopus citations

Abstract

One fundamental goal of personalized medicine is to provide tailored control of the dissolution rate for an oral dosage pill. Additive manufacturing of oral dose medicine allows for customized dissolution by tailoring both geometric and printed material properties. Direct processing of medicine via filament material extrusion is challenging because many active agents become inactive at the elevated temperatures found in the melt-based process. In this work, this limitation is circumvented by incorporating the active agents via in-situ embedding into a priori designed voids. This concept of embedding active ingredients into printed parts is demonstrated by the in-situ deposition of liquid ingredients into thin-walled, water soluble, printed structures. The authors demonstrate the ability to tune dissolution time by varying the thickness of the printed parts walls using this technique.

Original languageEnglish (US)
Pages2047-2059
Number of pages13
StatePublished - 2020
Externally publishedYes
Event28th Annual International Solid Freeform Fabrication Symposium - An Additive Manufacturing Conference, SFF 2017 - Austin, United States
Duration: Aug 7 2017Aug 9 2017

Conference

Conference28th Annual International Solid Freeform Fabrication Symposium - An Additive Manufacturing Conference, SFF 2017
CountryUnited States
CityAustin
Period8/7/178/9/17

Keywords

  • Dissolvable materials
  • Drug delivery
  • Embedding
  • Material extrusion

ASJC Scopus subject areas

  • Surfaces, Coatings and Films
  • Surfaces and Interfaces

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