A method for quantitatively determining the solution equilibrium for conformers in a conformationally mobile system by computer analysis of LIS spectra is developed. The relative population of the two major conformations of cis-8-oxabicyclo[4.3.0]non-3-ene and cis-2,5-dimethyl-cis-8-oxabicyclo[4.3.0]non-3-ene have been determined. A second, independent conformational analysis of these molecules supports the use of this method. Some limitations of shift reagents, as applied to conformational analysis, are examined.
ASJC Scopus subject areas
- Organic Chemistry