Eliminating partial-transformation products and mitigating residual toxicity of amoxicillin through intimately coupled photocatalysis and biodegradation

Yue Wang, Congli Chen, Dandan Zhou, Houfeng Xiong, Yihan Zhou, Shuangshi Dong, Bruce Rittmann

Research output: Contribution to journalArticle

Abstract

Intimately coupled photocatalysis and biodegradation (ICPB) is a promising technology for treating wastewater containing antibiotics. While past work has documented the benefits of ICPB for removing and mineralizing antibiotics, its impacts on mitigating biotoxicity from products has not been studied. We fabricated an ICPB carrier by coating Ag-doped TiO2 on the outer skeleton of sponge carriers and allowing biofilm to grow in the internal macro-pores. We used amoxicillin (C16H19N3O5S) as the model antibiotic. The amoxicillin-removal rate contents with ICPB was greater by 40% vs. photocatalysis and 65% vs. biodegradation, based on the first-order kinetic simulation. While mineralization of amoxicillin was minimal for photocatalysis or biodegradation alone, it was ∼35% with ICPB. Photocatalysis alone led to accumulation of C14H21N3O2S; biodegradation alone resulted in accumulation of C14H21N3O3, C16H18N2O4S, and C15H21N3O3; but they were negligible after ICPB. As a result, ICPB reduced toxicity impacts measured by Staphylococcus aureas growth, Daphnia magna mobility, and teratogenicity to Zebrafish embryos. In contrast, photocatalysis alone increased each of the toxicity effects. In sum, ICPB gave greater removal and mineralization of amoxicillin, and it mitigated biotoxicity from treatment products.

Original languageEnglish (US)
Article number124491
JournalChemosphere
Volume237
DOIs
StatePublished - Dec 1 2019

Fingerprint

Photocatalysis
Amoxicillin
Biodegradation
Toxicity
biodegradation
toxicity
Anti-Bacterial Agents
Daphnia
Porifera
Zebrafish
Antibiotics
Biofilms
antibiotics
Waste Water
Staphylococcus
Skeleton
Embryonic Structures
Technology
product
Growth

Keywords

  • Advanced oxidization
  • Antibiotics
  • Biodegradation
  • Ecotoxicity
  • Pathway

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Eliminating partial-transformation products and mitigating residual toxicity of amoxicillin through intimately coupled photocatalysis and biodegradation. / Wang, Yue; Chen, Congli; Zhou, Dandan; Xiong, Houfeng; Zhou, Yihan; Dong, Shuangshi; Rittmann, Bruce.

In: Chemosphere, Vol. 237, 124491, 01.12.2019.

Research output: Contribution to journalArticle

@article{11deba4ebcbc43ec9bcea3aa335b4226,
title = "Eliminating partial-transformation products and mitigating residual toxicity of amoxicillin through intimately coupled photocatalysis and biodegradation",
abstract = "Intimately coupled photocatalysis and biodegradation (ICPB) is a promising technology for treating wastewater containing antibiotics. While past work has documented the benefits of ICPB for removing and mineralizing antibiotics, its impacts on mitigating biotoxicity from products has not been studied. We fabricated an ICPB carrier by coating Ag-doped TiO2 on the outer skeleton of sponge carriers and allowing biofilm to grow in the internal macro-pores. We used amoxicillin (C16H19N3O5S) as the model antibiotic. The amoxicillin-removal rate contents with ICPB was greater by 40{\%} vs. photocatalysis and 65{\%} vs. biodegradation, based on the first-order kinetic simulation. While mineralization of amoxicillin was minimal for photocatalysis or biodegradation alone, it was ∼35{\%} with ICPB. Photocatalysis alone led to accumulation of C14H21N3O2S; biodegradation alone resulted in accumulation of C14H21N3O3, C16H18N2O4S, and C15H21N3O3; but they were negligible after ICPB. As a result, ICPB reduced toxicity impacts measured by Staphylococcus aureas growth, Daphnia magna mobility, and teratogenicity to Zebrafish embryos. In contrast, photocatalysis alone increased each of the toxicity effects. In sum, ICPB gave greater removal and mineralization of amoxicillin, and it mitigated biotoxicity from treatment products.",
keywords = "Advanced oxidization, Antibiotics, Biodegradation, Ecotoxicity, Pathway",
author = "Yue Wang and Congli Chen and Dandan Zhou and Houfeng Xiong and Yihan Zhou and Shuangshi Dong and Bruce Rittmann",
year = "2019",
month = "12",
day = "1",
doi = "10.1016/j.chemosphere.2019.124491",
language = "English (US)",
volume = "237",
journal = "Chemosphere",
issn = "0045-6535",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Eliminating partial-transformation products and mitigating residual toxicity of amoxicillin through intimately coupled photocatalysis and biodegradation

AU - Wang, Yue

AU - Chen, Congli

AU - Zhou, Dandan

AU - Xiong, Houfeng

AU - Zhou, Yihan

AU - Dong, Shuangshi

AU - Rittmann, Bruce

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Intimately coupled photocatalysis and biodegradation (ICPB) is a promising technology for treating wastewater containing antibiotics. While past work has documented the benefits of ICPB for removing and mineralizing antibiotics, its impacts on mitigating biotoxicity from products has not been studied. We fabricated an ICPB carrier by coating Ag-doped TiO2 on the outer skeleton of sponge carriers and allowing biofilm to grow in the internal macro-pores. We used amoxicillin (C16H19N3O5S) as the model antibiotic. The amoxicillin-removal rate contents with ICPB was greater by 40% vs. photocatalysis and 65% vs. biodegradation, based on the first-order kinetic simulation. While mineralization of amoxicillin was minimal for photocatalysis or biodegradation alone, it was ∼35% with ICPB. Photocatalysis alone led to accumulation of C14H21N3O2S; biodegradation alone resulted in accumulation of C14H21N3O3, C16H18N2O4S, and C15H21N3O3; but they were negligible after ICPB. As a result, ICPB reduced toxicity impacts measured by Staphylococcus aureas growth, Daphnia magna mobility, and teratogenicity to Zebrafish embryos. In contrast, photocatalysis alone increased each of the toxicity effects. In sum, ICPB gave greater removal and mineralization of amoxicillin, and it mitigated biotoxicity from treatment products.

AB - Intimately coupled photocatalysis and biodegradation (ICPB) is a promising technology for treating wastewater containing antibiotics. While past work has documented the benefits of ICPB for removing and mineralizing antibiotics, its impacts on mitigating biotoxicity from products has not been studied. We fabricated an ICPB carrier by coating Ag-doped TiO2 on the outer skeleton of sponge carriers and allowing biofilm to grow in the internal macro-pores. We used amoxicillin (C16H19N3O5S) as the model antibiotic. The amoxicillin-removal rate contents with ICPB was greater by 40% vs. photocatalysis and 65% vs. biodegradation, based on the first-order kinetic simulation. While mineralization of amoxicillin was minimal for photocatalysis or biodegradation alone, it was ∼35% with ICPB. Photocatalysis alone led to accumulation of C14H21N3O2S; biodegradation alone resulted in accumulation of C14H21N3O3, C16H18N2O4S, and C15H21N3O3; but they were negligible after ICPB. As a result, ICPB reduced toxicity impacts measured by Staphylococcus aureas growth, Daphnia magna mobility, and teratogenicity to Zebrafish embryos. In contrast, photocatalysis alone increased each of the toxicity effects. In sum, ICPB gave greater removal and mineralization of amoxicillin, and it mitigated biotoxicity from treatment products.

KW - Advanced oxidization

KW - Antibiotics

KW - Biodegradation

KW - Ecotoxicity

KW - Pathway

UR - http://www.scopus.com/inward/record.url?scp=85070111915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070111915&partnerID=8YFLogxK

U2 - 10.1016/j.chemosphere.2019.124491

DO - 10.1016/j.chemosphere.2019.124491

M3 - Article

C2 - 31394448

AN - SCOPUS:85070111915

VL - 237

JO - Chemosphere

JF - Chemosphere

SN - 0045-6535

M1 - 124491

ER -