Electronic signatures of all four DNA nucleosides in a tunneling gap

Shuai Chang, Shuo Huang, Jin He, Feng Liang, Peiming Zhang, Shengqing Li, Xiang Chen, Otto Sankey, Stuart Lindsay

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

Nucleosides diffusing through a 2 nm electron-tunneling junction generate current spikes of sub-millisecond duration with a broad distribution of peak currents. This distribution narrows 10-fold when one of the electrodes is functionalized with a reagent that traps nucleosides in a specific orientation with hydrogen bonds. Functionalizing the second electrode reduces contact resistance to the nucleosides, allowing them to be identified via their peak currents according to deoxyadenosine > deoxycytidine > deoxyguanosine > thymidine, in agreement with the order predicted by a density functional calculation.

Original languageEnglish (US)
Pages (from-to)1070-1075
Number of pages6
JournalNano Letters
Volume10
Issue number3
DOIs
StatePublished - Mar 10 2010

Fingerprint

nucleosides
Nucleosides
DNA
deoxyribonucleic acid
signatures
electronics
thymidine
Deoxycytidine
Electrodes
Deoxyguanosine
Electron tunneling
electrodes
Contact resistance
electron tunneling
contact resistance
spikes
Thymidine
Density functional theory
reagents
Hydrogen bonds

Keywords

  • DNA nucleosides
  • DNA sequencing
  • Electron tunneling
  • Hydrogen bonding
  • Molecular recognition

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering

Cite this

Chang, S., Huang, S., He, J., Liang, F., Zhang, P., Li, S., ... Lindsay, S. (2010). Electronic signatures of all four DNA nucleosides in a tunneling gap. Nano Letters, 10(3), 1070-1075. https://doi.org/10.1021/nl1001185

Electronic signatures of all four DNA nucleosides in a tunneling gap. / Chang, Shuai; Huang, Shuo; He, Jin; Liang, Feng; Zhang, Peiming; Li, Shengqing; Chen, Xiang; Sankey, Otto; Lindsay, Stuart.

In: Nano Letters, Vol. 10, No. 3, 10.03.2010, p. 1070-1075.

Research output: Contribution to journalArticle

Chang, S, Huang, S, He, J, Liang, F, Zhang, P, Li, S, Chen, X, Sankey, O & Lindsay, S 2010, 'Electronic signatures of all four DNA nucleosides in a tunneling gap', Nano Letters, vol. 10, no. 3, pp. 1070-1075. https://doi.org/10.1021/nl1001185
Chang S, Huang S, He J, Liang F, Zhang P, Li S et al. Electronic signatures of all four DNA nucleosides in a tunneling gap. Nano Letters. 2010 Mar 10;10(3):1070-1075. https://doi.org/10.1021/nl1001185
Chang, Shuai ; Huang, Shuo ; He, Jin ; Liang, Feng ; Zhang, Peiming ; Li, Shengqing ; Chen, Xiang ; Sankey, Otto ; Lindsay, Stuart. / Electronic signatures of all four DNA nucleosides in a tunneling gap. In: Nano Letters. 2010 ; Vol. 10, No. 3. pp. 1070-1075.
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