Electronic signatures of all four DNA nucleosides in a tunneling gap

Shuai Chang; Shuo Huang; Jin He; Feng Liang; Peiming Zhang; Shengqing Li; Xiang Chen; Otto Sankey; Stuart Lindsay

doi:10.1021/nl1001185

Electronic signatures of all four DNA nucleosides in a tunneling gap

Shuai Chang, Shuo Huang, Jin He, Feng Liang, Peiming Zhang, Shengqing Li, Xiang Chen, Otto Sankey, Stuart Lindsay

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Abstract

Nucleosides diffusing through a 2 nm electron-tunneling junction generate current spikes of sub-millisecond duration with a broad distribution of peak currents. This distribution narrows 10-fold when one of the electrodes is functionalized with a reagent that traps nucleosides in a specific orientation with hydrogen bonds. Functionalizing the second electrode reduces contact resistance to the nucleosides, allowing them to be identified via their peak currents according to deoxyadenosine > deoxycytidine > deoxyguanosine > thymidine, in agreement with the order predicted by a density functional calculation.

Original language	English (US)
Pages (from-to)	1070-1075
Number of pages	6
Journal	Nano Letters
Volume	10
Issue number	3
DOIs	https://doi.org/10.1021/nl1001185
State	Published - Mar 10 2010

Keywords

DNA nucleosides
DNA sequencing
Electron tunneling
Hydrogen bonding
Molecular recognition

ASJC Scopus subject areas

Bioengineering
Chemistry(all)
Materials Science(all)
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl1001185

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abstract = "Nucleosides diffusing through a 2 nm electron-tunneling junction generate current spikes of sub-millisecond duration with a broad distribution of peak currents. This distribution narrows 10-fold when one of the electrodes is functionalized with a reagent that traps nucleosides in a specific orientation with hydrogen bonds. Functionalizing the second electrode reduces contact resistance to the nucleosides, allowing them to be identified via their peak currents according to deoxyadenosine > deoxycytidine > deoxyguanosine > thymidine, in agreement with the order predicted by a density functional calculation.",

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T1 - Electronic signatures of all four DNA nucleosides in a tunneling gap

AU - Chang, Shuai

AU - Huang, Shuo

AU - He, Jin

AU - Liang, Feng

AU - Zhang, Peiming

AU - Li, Shengqing

AU - Chen, Xiang

AU - Sankey, Otto

AU - Lindsay, Stuart

PY - 2010/3/10

Y1 - 2010/3/10

N2 - Nucleosides diffusing through a 2 nm electron-tunneling junction generate current spikes of sub-millisecond duration with a broad distribution of peak currents. This distribution narrows 10-fold when one of the electrodes is functionalized with a reagent that traps nucleosides in a specific orientation with hydrogen bonds. Functionalizing the second electrode reduces contact resistance to the nucleosides, allowing them to be identified via their peak currents according to deoxyadenosine > deoxycytidine > deoxyguanosine > thymidine, in agreement with the order predicted by a density functional calculation.

AB - Nucleosides diffusing through a 2 nm electron-tunneling junction generate current spikes of sub-millisecond duration with a broad distribution of peak currents. This distribution narrows 10-fold when one of the electrodes is functionalized with a reagent that traps nucleosides in a specific orientation with hydrogen bonds. Functionalizing the second electrode reduces contact resistance to the nucleosides, allowing them to be identified via their peak currents according to deoxyadenosine > deoxycytidine > deoxyguanosine > thymidine, in agreement with the order predicted by a density functional calculation.

KW - DNA nucleosides

KW - DNA sequencing

KW - Electron tunneling

KW - Hydrogen bonding

KW - Molecular recognition

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Electronic signatures of all four DNA nucleosides in a tunneling gap

Abstract

Keywords

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