Electrodiffusion model simulation of the potassium channel

Carl Gardner, Jeremiah R. Jones

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The drift-diffusion (Poisson-Nernst-Planck) model is applied to the potassium channel in a biological membrane plus surrounding solution baths. Two-dimensional cylindrically symmetric simulations of the K channel in KCl solutions are presented which show significant boundary layers at the ends of the channel and display the spreading of charge into the bath regions. The computed current-voltage curve shows excellent agreement with experimental measurements. In addition, the response of the K channel to time-dependent applied voltages is investigated.

Original languageEnglish (US)
Pages (from-to)10-13
Number of pages4
JournalJournal of Theoretical Biology
Volume291
Issue number1
DOIs
StatePublished - Dec 21 2011

Fingerprint

K+ Channel
Potassium Channels
potassium channels
Baths
Potassium
simulation models
Simulation Model
Voltage
Biological membranes
Drift-diffusion
Electric potential
Boundary Layer
Siméon Denis Poisson
Boundary layers
Membrane
Charge
Curve
Membranes
Simulation
Model

Keywords

  • Biological channel
  • Ion transport
  • PNP model

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Modeling and Simulation
  • Statistics and Probability
  • Applied Mathematics

Cite this

Electrodiffusion model simulation of the potassium channel. / Gardner, Carl; Jones, Jeremiah R.

In: Journal of Theoretical Biology, Vol. 291, No. 1, 21.12.2011, p. 10-13.

Research output: Contribution to journalArticle

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