Electrodiffusion model simulation of the potassium channel

Carl Gardner; Jeremiah R. Jones

doi:10.1016/j.jtbi.2011.09.010

Electrodiffusion model simulation of the potassium channel

Carl Gardner, Jeremiah R. Jones

CLAS-NS: Mathematics and Statistical Sciences, School of (SMSS)

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The drift-diffusion (Poisson-Nernst-Planck) model is applied to the potassium channel in a biological membrane plus surrounding solution baths. Two-dimensional cylindrically symmetric simulations of the K channel in KCl solutions are presented which show significant boundary layers at the ends of the channel and display the spreading of charge into the bath regions. The computed current-voltage curve shows excellent agreement with experimental measurements. In addition, the response of the K channel to time-dependent applied voltages is investigated.

Original language	English (US)
Pages (from-to)	10-13
Number of pages	4
Journal	Journal of Theoretical Biology
Volume	291
Issue number	1
DOIs	https://doi.org/10.1016/j.jtbi.2011.09.010
State	Published - Dec 21 2011

Keywords

Biological channel
Ion transport
PNP model

ASJC Scopus subject areas

Statistics and Probability
Modeling and Simulation
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Agricultural and Biological Sciences(all)
Applied Mathematics

Access to Document

10.1016/j.jtbi.2011.09.010

Fingerprint Dive into the research topics of 'Electrodiffusion model simulation of the potassium channel'. Together they form a unique fingerprint.

Cite this

@article{bf8cc531e4894e65a503a92facaa908b,

title = "Electrodiffusion model simulation of the potassium channel",

abstract = "The drift-diffusion (Poisson-Nernst-Planck) model is applied to the potassium channel in a biological membrane plus surrounding solution baths. Two-dimensional cylindrically symmetric simulations of the K channel in KCl solutions are presented which show significant boundary layers at the ends of the channel and display the spreading of charge into the bath regions. The computed current-voltage curve shows excellent agreement with experimental measurements. In addition, the response of the K channel to time-dependent applied voltages is investigated.",

keywords = "Biological channel, Ion transport, PNP model",

author = "Carl Gardner and Jones, {Jeremiah R.}",

year = "2011",

month = dec,

day = "21",

doi = "10.1016/j.jtbi.2011.09.010",

language = "English (US)",

volume = "291",

pages = "10--13",

journal = "Journal of Theoretical Biology",

issn = "0022-5193",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Electrodiffusion model simulation of the potassium channel

AU - Gardner, Carl

AU - Jones, Jeremiah R.

PY - 2011/12/21

Y1 - 2011/12/21

N2 - The drift-diffusion (Poisson-Nernst-Planck) model is applied to the potassium channel in a biological membrane plus surrounding solution baths. Two-dimensional cylindrically symmetric simulations of the K channel in KCl solutions are presented which show significant boundary layers at the ends of the channel and display the spreading of charge into the bath regions. The computed current-voltage curve shows excellent agreement with experimental measurements. In addition, the response of the K channel to time-dependent applied voltages is investigated.

AB - The drift-diffusion (Poisson-Nernst-Planck) model is applied to the potassium channel in a biological membrane plus surrounding solution baths. Two-dimensional cylindrically symmetric simulations of the K channel in KCl solutions are presented which show significant boundary layers at the ends of the channel and display the spreading of charge into the bath regions. The computed current-voltage curve shows excellent agreement with experimental measurements. In addition, the response of the K channel to time-dependent applied voltages is investigated.

KW - Biological channel

KW - Ion transport

KW - PNP model

UR - http://www.scopus.com/inward/record.url?scp=80053345883&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053345883&partnerID=8YFLogxK

U2 - 10.1016/j.jtbi.2011.09.010

DO - 10.1016/j.jtbi.2011.09.010

M3 - Article

C2 - 21945149

AN - SCOPUS:80053345883

VL - 291

SP - 10

EP - 13

JO - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

SN - 0022-5193

IS - 1

ER -

Electrodiffusion model simulation of the potassium channel

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this