Abstract
The drift-diffusion (Poisson-Nernst-Planck) model is applied to the potassium channel in a biological membrane plus surrounding solution baths. Two-dimensional cylindrically symmetric simulations of the K channel in KCl solutions are presented which show significant boundary layers at the ends of the channel and display the spreading of charge into the bath regions. The computed current-voltage curve shows excellent agreement with experimental measurements. In addition, the response of the K channel to time-dependent applied voltages is investigated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 10-13 |
| Number of pages | 4 |
| Journal | Journal of Theoretical Biology |
| Volume | 291 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 21 2011 |
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Keywords
- Biological channel
- Ion transport
- PNP model
ASJC Scopus subject areas
- Medicine(all)
- Immunology and Microbiology(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)
- Modeling and Simulation
- Statistics and Probability
- Applied Mathematics
Cite this
Electrodiffusion model simulation of the potassium channel. / Gardner, Carl; Jones, Jeremiah R.
In: Journal of Theoretical Biology, Vol. 291, No. 1, 21.12.2011, p. 10-13.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Electrodiffusion model simulation of the potassium channel
AU - Gardner, Carl
AU - Jones, Jeremiah R.
PY - 2011/12/21
Y1 - 2011/12/21
N2 - The drift-diffusion (Poisson-Nernst-Planck) model is applied to the potassium channel in a biological membrane plus surrounding solution baths. Two-dimensional cylindrically symmetric simulations of the K channel in KCl solutions are presented which show significant boundary layers at the ends of the channel and display the spreading of charge into the bath regions. The computed current-voltage curve shows excellent agreement with experimental measurements. In addition, the response of the K channel to time-dependent applied voltages is investigated.
AB - The drift-diffusion (Poisson-Nernst-Planck) model is applied to the potassium channel in a biological membrane plus surrounding solution baths. Two-dimensional cylindrically symmetric simulations of the K channel in KCl solutions are presented which show significant boundary layers at the ends of the channel and display the spreading of charge into the bath regions. The computed current-voltage curve shows excellent agreement with experimental measurements. In addition, the response of the K channel to time-dependent applied voltages is investigated.
KW - Biological channel
KW - Ion transport
KW - PNP model
UR - http://www.scopus.com/inward/record.url?scp=80053345883&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053345883&partnerID=8YFLogxK
U2 - 10.1016/j.jtbi.2011.09.010
DO - 10.1016/j.jtbi.2011.09.010
M3 - Article
C2 - 21945149
AN - SCOPUS:80053345883
VL - 291
SP - 10
EP - 13
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
SN - 0022-5193
IS - 1
ER -