Electrodiffusion model simulation of the potassium channel

Carl Gardner, Jeremiah R. Jones

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The drift-diffusion (Poisson-Nernst-Planck) model is applied to the potassium channel in a biological membrane plus surrounding solution baths. Two-dimensional cylindrically symmetric simulations of the K channel in KCl solutions are presented which show significant boundary layers at the ends of the channel and display the spreading of charge into the bath regions. The computed current-voltage curve shows excellent agreement with experimental measurements. In addition, the response of the K channel to time-dependent applied voltages is investigated.

Original languageEnglish (US)
Pages (from-to)10-13
Number of pages4
JournalJournal of Theoretical Biology
Volume291
Issue number1
DOIs
StatePublished - Dec 21 2011

Keywords

  • Biological channel
  • Ion transport
  • PNP model

ASJC Scopus subject areas

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Fingerprint Dive into the research topics of 'Electrodiffusion model simulation of the potassium channel'. Together they form a unique fingerprint.

Cite this