Electrochemical glutamate biosensing with nanocube and nanosphere augmented single-walled carbon nanotube networks: A comparative study

Jonathan C. Claussen, Mayra S. Artiles, Eric S. McLamore, Subhashree Mohanty, Jin Shi, Jenna L. Rickus, Timothy S. Fisher, D. Marshall Porterfield

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

We describe two hybrid nanomaterial biosensor platforms, based on networks of single-walled carbon nanotubes (SWCNTs) enhanced with Pd nanocubes and Pt nanospheres and grown in situ from a porous anodic alumina (PAA) template. These nanocube and nanosphere SWCNT networks are converted into glutamate biosensors by immobilizing the enzyme glutamate oxidase (cross-linked with gluteraldehyde) onto the electrode surface. The Pt nanosphere/SWCNT biosensor outperformed the Pd nanocube/SWCNT biosensor and previously reported similar nanomaterial-based biosensors by amperometrically monitoring glutamate concentrations with a wide linear sensing range (50 nM to 1.6 mM) and a small detection limit (4.6 nM, 3σ). These results combined with the biosensor fabrication scheme (in situ growth of SWCNTs, electrodeposition of metal nanoparticles, and facile enzyme immobilization protocol) create a biosensor that can potentially be scaled for integration into a wide range of applications including the treatment of neurological disorders.

Original languageEnglish (US)
Pages (from-to)11224-11231
Number of pages8
JournalJournal of Materials Chemistry
Volume21
Issue number30
DOIs
StatePublished - Aug 14 2011
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Electrochemical glutamate biosensing with nanocube and nanosphere augmented single-walled carbon nanotube networks: A comparative study'. Together they form a unique fingerprint.

Cite this