Eicosanoids and the large intestine

Wade Krause, Raymond N. Dubois

    Research output: Contribution to journalReview articlepeer-review

    29 Scopus citations

    Abstract

    During the past three decades, many studies have been conducted to determine the precise role of eicosanoids in colorectal physiology and pathophysiology. This research has increased our understanding of bioactive lipid signaling, and may contribute to the development of more effective therapeutic modalities for digestive diseases in the future. The purpose of this report is to provide a brief overview of the role of eicosanoids in the colon and rectum. This information has been organized according to both functional and disease-related categories. The role of eicosanoids in colonic secretion, motility, inflammatory bowel disease, and colorectal neoplasia will be discussed. Copyright (C) 2000 Elsevier Science Inc.

    Original languageEnglish (US)
    Pages (from-to)145-161
    Number of pages17
    JournalProstaglandins and Other Lipid Mediators
    Volume61
    Issue number3-4
    DOIs
    StatePublished - May 2000

    Keywords

    • Colon
    • Colorectal cancer
    • Eicosanoids
    • Inflammatory bowel disease
    • Ion transport
    • Secretion

    ASJC Scopus subject areas

    • Biochemistry
    • Physiology
    • Pharmacology
    • Cell Biology

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