Eicosanoids and the gastrointestinal tract

Charles E. Eberhart; Raymond N. Dubois

doi:10.1016/0016-5085(95)90296-1

Eicosanoids and the gastrointestinal tract

Charles E. Eberhart, Raymond N. Dubois

Research output: Contribution to journal › Article › peer-review

410 Scopus citations

Abstract

Determining the role of eicosanoids in gastrointestinal physiology and pathophysiology has been an active area of investigation over the past 20 years. The landmark discovery of prostaglandin endoperoxide synthase and other enzymes involved in the production of arachidonic acid products (lipoxygenases and epoxygenases) ushered in a new era of research. The goal of this review is to distill a large body of work pertaining to studies of eicosanoids in the gastrointestinal tract. This review has been organized according both to functional (secretion and motility) and disease-related (inflammation, mucosal injury, and neoplasia) effects. The aim of this article is to present a clear summary of this area of gastroenterology so that future research can be directed in a logical and productive manner.

Original language	English (US)
Pages (from-to)	285-301
Number of pages	17
Journal	Gastroenterology
Volume	109
Issue number	1
DOIs	https://doi.org/10.1016/0016-5085(95)90296-1
State	Published - Jul 1995
Externally published	Yes

ASJC Scopus subject areas

Hepatology
Gastroenterology

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10.1016/0016-5085(95)90296-1

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title = "Eicosanoids and the gastrointestinal tract",

abstract = "Determining the role of eicosanoids in gastrointestinal physiology and pathophysiology has been an active area of investigation over the past 20 years. The landmark discovery of prostaglandin endoperoxide synthase and other enzymes involved in the production of arachidonic acid products (lipoxygenases and epoxygenases) ushered in a new era of research. The goal of this review is to distill a large body of work pertaining to studies of eicosanoids in the gastrointestinal tract. This review has been organized according both to functional (secretion and motility) and disease-related (inflammation, mucosal injury, and neoplasia) effects. The aim of this article is to present a clear summary of this area of gastroenterology so that future research can be directed in a logical and productive manner.",

author = "Eberhart, {Charles E.} and Dubois, {Raymond N.}",

note = "Funding Information: Supported by A. B. Hancock, Jr., Memorial Laboratory, Lucille P. Markey Charitable Trust, and US Public Health DK 47297-01A1 (to R.N.D.) and T32 DKO7673-OIA1 (to C.E.E.). Dr. DuBois is a recipient of a Veterans Affairs Research Associate Career DevelopmentA ward and a Boehringer Ingelheim New Investigator Award, and Dr. DuBois is an American Gastroenterological Association Research Scholar.",

year = "1995",

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doi = "10.1016/0016-5085(95)90296-1",

language = "English (US)",

volume = "109",

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journal = "Gastroenterology",

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publisher = "W.B. Saunders Ltd",

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AU - Eberhart, Charles E.

AU - Dubois, Raymond N.

N1 - Funding Information: Supported by A. B. Hancock, Jr., Memorial Laboratory, Lucille P. Markey Charitable Trust, and US Public Health DK 47297-01A1 (to R.N.D.) and T32 DKO7673-OIA1 (to C.E.E.). Dr. DuBois is a recipient of a Veterans Affairs Research Associate Career DevelopmentA ward and a Boehringer Ingelheim New Investigator Award, and Dr. DuBois is an American Gastroenterological Association Research Scholar.

PY - 1995/7

Y1 - 1995/7

N2 - Determining the role of eicosanoids in gastrointestinal physiology and pathophysiology has been an active area of investigation over the past 20 years. The landmark discovery of prostaglandin endoperoxide synthase and other enzymes involved in the production of arachidonic acid products (lipoxygenases and epoxygenases) ushered in a new era of research. The goal of this review is to distill a large body of work pertaining to studies of eicosanoids in the gastrointestinal tract. This review has been organized according both to functional (secretion and motility) and disease-related (inflammation, mucosal injury, and neoplasia) effects. The aim of this article is to present a clear summary of this area of gastroenterology so that future research can be directed in a logical and productive manner.

AB - Determining the role of eicosanoids in gastrointestinal physiology and pathophysiology has been an active area of investigation over the past 20 years. The landmark discovery of prostaglandin endoperoxide synthase and other enzymes involved in the production of arachidonic acid products (lipoxygenases and epoxygenases) ushered in a new era of research. The goal of this review is to distill a large body of work pertaining to studies of eicosanoids in the gastrointestinal tract. This review has been organized according both to functional (secretion and motility) and disease-related (inflammation, mucosal injury, and neoplasia) effects. The aim of this article is to present a clear summary of this area of gastroenterology so that future research can be directed in a logical and productive manner.

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VL - 109

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JO - Gastroenterology

JF - Gastroenterology

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ER -

Eicosanoids and the gastrointestinal tract

Abstract

ASJC Scopus subject areas

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