Eicosanoids and cancer

Dingzhi Wang, Raymond N. Dubois

Research output: Contribution to journalReview article

958 Scopus citations

Abstract

Eicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that have been implicated in various pathological processes, such as inflammation and cancer. This Review highlights our understanding of the intricate roles of eicosanoids in epithelial-derived tumours and their microenvironment. The knowledge of how these lipids orchestrate the complex interactions between transformed epithelial cells and the surrounding stromal cells is crucial for understanding tumour evolution, progression and metastasis. Understanding the molecular mechanisms underlying the role of prostaglandins and other eicosanoids in cancer progression will help to develop more effective cancer chemopreventive and/or therapeutic agents.

Original languageEnglish (US)
Pages (from-to)181-193
Number of pages13
JournalNature Reviews Cancer
Volume10
Issue number3
DOIs
StatePublished - Mar 1 2010

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Wang, D., & Dubois, R. N. (2010). Eicosanoids and cancer. Nature Reviews Cancer, 10(3), 181-193. https://doi.org/10.1038/nrc2809