Egg desiccation leads to dehydration and enhanced innate immunity in python embryos

George A. Brusch, Dale Denardo

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    The immune system is essential for survival and its performance can vary depending on the physiological state of the organism. Much of the current research into immune function dynamics has examined newborn to adult life stages, despite previous studies documenting physiological responses in embryos to environmental stimuli. While energy balance has been the predominant focus as the driver of changes in immune function, recent research has found a positive relationship between dehydration and innate immune performance in adult reptiles. We expanded the understanding of this relationship by examining trans-generational immune effects of female dehydration as well as the effects of egg desiccation on embryonic hydration state and innate immunity using Children's pythons, Antaresia childreni. We used a 2 × 2 experiment with hydrated or dehydrated mothers and eggs either incubated under continuous optimal conditions or experiencing desiccating conditions for 24 h. Our results demonstrate that, similar to adults, embryos enhance some metrics of innate immunity when they are dehydrated.

    Original languageEnglish (US)
    Pages (from-to)147-151
    Number of pages5
    JournalDevelopmental and Comparative Immunology
    Volume90
    DOIs
    StatePublished - Jan 1 2019

    Fingerprint

    Boidae
    Desiccation
    Dehydration
    Innate Immunity
    Ovum
    Embryonic Structures
    Reptiles
    Research
    Eggs
    Immune System
    Mothers
    Newborn Infant

    Keywords

    • Dehydration
    • Embryonic immunity
    • Immunocompetence
    • Innate immunity

    ASJC Scopus subject areas

    • Immunology
    • Developmental Biology

    Cite this

    Egg desiccation leads to dehydration and enhanced innate immunity in python embryos. / Brusch, George A.; Denardo, Dale.

    In: Developmental and Comparative Immunology, Vol. 90, 01.01.2019, p. 147-151.

    Research output: Contribution to journalArticle

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