TY - JOUR
T1 - Effects of treatment and prevalence-dependent recruitment on the dynamics of a fatal disease
AU - Velasco-Hernández, Jorge X.
AU - Brauer, Fred
AU - Castillo-Chavez, Carlos
N1 - Funding Information:
This research was partially supported by NSF grant DEB-925370 (Presidential Faculty Fellowship Award) to Carlos Castillo-Chavez and by the US Army Research Office through the Mathematical Science Institute of Cornell University (contract DAALO3-91-C-OO27). Jorge X. Velasco-Hernandez's research was partially supported by the Consejo Nacional de Ciencia y Tecnologia de Mexico (CONACYT) through grant 4OO2OO-5-355IE.
PY - 1996/9
Y1 - 1996/9
N2 - This paper studies models for the sexual transmission of HIV/AIDS that incorporate changes in behaviour and the effects associated with HIV treatment. The recruitment rate into the core is assumed to be a function of the prevalence of the disease within the core, and it may trigger the existence of periodic solutions through Hopf bifurcations, provided that there is at least a weak demographic interaction with the noncore. The recruitment function is set up for two cases: dependence on the total proportion of infectious individuals and dependence on the proportion of treated infectious individuals only. In the general model, numerical evidence suggests that both cases may produce periodic solutions when the perception of the risk of joining the core group is sufficiently high. Two limiting cases are also studied: when the growth rate of the core and noncore groups are essentially the same, and when treatment has no effect on the transmission rate of infected individuals.
AB - This paper studies models for the sexual transmission of HIV/AIDS that incorporate changes in behaviour and the effects associated with HIV treatment. The recruitment rate into the core is assumed to be a function of the prevalence of the disease within the core, and it may trigger the existence of periodic solutions through Hopf bifurcations, provided that there is at least a weak demographic interaction with the noncore. The recruitment function is set up for two cases: dependence on the total proportion of infectious individuals and dependence on the proportion of treated infectious individuals only. In the general model, numerical evidence suggests that both cases may produce periodic solutions when the perception of the risk of joining the core group is sufficiently high. Two limiting cases are also studied: when the growth rate of the core and noncore groups are essentially the same, and when treatment has no effect on the transmission rate of infected individuals.
KW - Behavioural change
KW - Core groups
KW - Differential equations
KW - HIV population dynamics
KW - Mathematical models
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U2 - 10.1093/imammb13.3.175
DO - 10.1093/imammb13.3.175
M3 - Article
C2 - 8921588
AN - SCOPUS:0030237780
SN - 1477-8599
VL - 13
SP - 175
EP - 192
JO - Mathematical Medicine and Biology
JF - Mathematical Medicine and Biology
IS - 3
ER -