Effects of the mGluR2/3 agonist LY379268 and the mGluR5 antagonist MPEP on handling-induced convulsions during ethanol withdrawal in mice

Medicine & Life Sciences

• LY 379268 100%
• metabotropic glutamate receptor 2 87%
• pyridine 73%
• Psychological Handling 71%
• Ethanol 48%
• Seizures 44%
• Substance Withdrawal Syndrome 28%
• Psychological Inhibition 27%
• 3-methyl-6-(phenylethynyl)pyridine 25%
• Anticonvulsants 21%
• Glutamic Acid 20%
• 6-methyl-2-(phenylethynyl)pyridine 19%
• Alcohols 17%
• Central Nervous System Sensitization 15%
• Inhalation Exposure 15%
• Metabotropic Glutamate Receptors 14%
• Inbred C3H Mouse 13%
• Alcoholics 12%
• Benzodiazepines 11%
• Central Nervous System 8%
• Therapeutics 1%

Chemical Compounds

• Convulsion 83%
• Agonist 54%
• Antagonist 52%
• Ethanol 36%
• Anticonvulsant 26%
• 2-methyl-6-(phenylethynyl)pyridine 22%
• Alcohol 13%
• Benzodiazepine 13%
• Sensitization 12%
• Reduction 5%

Social Sciences

• withdrawal 54%
• intoxication 15%
• alcohol 9%
• sensitization 8%
• seizure 7%
• chamber 6%
• alcoholism 6%
• medication 5%
• evidence 2%