Effects of relative humidity, temperature, and geometry on fluid flow rate in lateral flow immunoassays

Nipun Thamatam, Jennifer Blain Christen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Lateral Flow Immunoassays (LFIAs) are among the most successful Point of Care (POC) tests. However, factors like reagent stability, reaction rates, and binding kinetics limit the performance and robustness of LFIAs. One of the factors that affects the overall performance of LFIA is the fluid flow rate, and hence, it is desirable to maintain a predictable fluid velocity in porous media. The main objective of this study is to build a statistical model that estimates the fluid velocity in porous media for any given ambient condition to enable us to determine the optimal design parameters for achieving a desired fluid velocity in porous media.

Original languageEnglish (US)
Title of host publication2019 IEEE Healthcare Innovations and Point of Care Technologies, HI-POCT 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages75-79
Number of pages5
ISBN (Electronic)9781728138121
DOIs
StatePublished - Nov 2019
Externally publishedYes
Event2019 IEEE Healthcare Innovations and Point of Care Technologies, HI-POCT 2019 - Bethesda, United States
Duration: Nov 20 2019Nov 22 2019

Publication series

Name2019 IEEE Healthcare Innovations and Point of Care Technologies, HI-POCT 2019

Conference

Conference2019 IEEE Healthcare Innovations and Point of Care Technologies, HI-POCT 2019
CountryUnited States
CityBethesda
Period11/20/1911/22/19

Keywords

  • design of experiments
  • evaporation
  • fluid flow rate
  • geometry
  • porous media

ASJC Scopus subject areas

  • Artificial Intelligence
  • Computer Science Applications
  • Biomedical Engineering
  • Health Informatics
  • Instrumentation
  • Health(social science)

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  • Cite this

    Thamatam, N., & Christen, J. B. (2019). Effects of relative humidity, temperature, and geometry on fluid flow rate in lateral flow immunoassays. In 2019 IEEE Healthcare Innovations and Point of Care Technologies, HI-POCT 2019 (pp. 75-79). [8962702] (2019 IEEE Healthcare Innovations and Point of Care Technologies, HI-POCT 2019). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/HI-POCT45284.2019.8962702