Effects of prenatal alcohol exposure on testosterone and pubertal development

R. Colin Carter, Joseph L. Jacobson, Neil C. Dodge, Douglas A. Granger, Sandra W. Jacobson

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: animal models have demonstrated fetal alcohol-related disruptions in neuroendocrine function in the hypothalamic-pituitary-gonadal axis and downstream effects on pubertal development and sexual behavior in males and females, but little is known about these effects in humans. this study examined whether prenatal alcohol exposure is associated with alterations in testosterone during adolescence and whether it affects timing of pubertal development. methods: the sample consisted of 265 african american adolescents from the detroit longitudinal cohort study for whom testosterone and/or pubertal development data were available. subjects were offspring of women recruited at their first prenatal clinic visit to over represent moderate-to-heavy alcohol use, including a 5% random sample of low-level drinkers/abstainers. mothers were interviewed at every prenatal visit about their alcohol consumption using a timeline follow-back approach and about their smoking and drug use and sociodemographic factors. at age 14 years, adolescents provided salivary samples, which were analyzed for testosterone (pg/ml), self-reported tanner stages for pubertal development, and age at menarche (females). results: prenatal alcohol exposure was related to elevated testosterone concentrations for males and females but not to changes in tanner stages or age at menarche, after controlling for confounders. in regression models stratified by alcohol exposure, the expected relation between testosterone and pubic hair development was seen among males with light-to-no prenatal alcohol exposure, but not among those with moderate-to-heavy prenatal alcohol exposure. this interaction between testosterone and prenatal alcohol exposure was confirmed in multivariable models including an alcohol exposure group × testosterone interaction term and potential confounders. conclusions: this study is the first to show a relation between prenatal alcohol exposure and increased testosterone during adolescence and evidence of decreased testosterone responsiveness in tissues related to pubertal development in humans. further studies examining androgen receptor expression and other hormonal and cellular factors affecting pubertal development may reveal important mechanisms underlying these teratogenic effects of alcohol exposure.

Original languageEnglish (US)
Pages (from-to)1671-1679
Number of pages9
JournalAlcoholism: Clinical and Experimental Research
Volume38
Issue number6
DOIs
StatePublished - 2014

Fingerprint

Testosterone
Alcohols
Menarche
Androgen Receptors
Human Development
Ambulatory Care
Sexual Behavior
Alcohol Drinking
African Americans
Hair
Longitudinal Studies
Cohort Studies
Animal Models
Smoking
Animals
Mothers
Light
Tissue

Keywords

  • fetal alcohol spectrum disorder
  • prenatal alcohol exposure
  • puberty
  • tanner stages
  • testosterone

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health
  • Toxicology
  • Medicine(all)

Cite this

Carter, R. C., Jacobson, J. L., Dodge, N. C., Granger, D. A., & Jacobson, S. W. (2014). Effects of prenatal alcohol exposure on testosterone and pubertal development. Alcoholism: Clinical and Experimental Research, 38(6), 1671-1679. https://doi.org/10.1111/acer.12395

Effects of prenatal alcohol exposure on testosterone and pubertal development. / Carter, R. Colin; Jacobson, Joseph L.; Dodge, Neil C.; Granger, Douglas A.; Jacobson, Sandra W.

In: Alcoholism: Clinical and Experimental Research, Vol. 38, No. 6, 2014, p. 1671-1679.

Research output: Contribution to journalArticle

Carter, RC, Jacobson, JL, Dodge, NC, Granger, DA & Jacobson, SW 2014, 'Effects of prenatal alcohol exposure on testosterone and pubertal development', Alcoholism: Clinical and Experimental Research, vol. 38, no. 6, pp. 1671-1679. https://doi.org/10.1111/acer.12395
Carter, R. Colin ; Jacobson, Joseph L. ; Dodge, Neil C. ; Granger, Douglas A. ; Jacobson, Sandra W. / Effects of prenatal alcohol exposure on testosterone and pubertal development. In: Alcoholism: Clinical and Experimental Research. 2014 ; Vol. 38, No. 6. pp. 1671-1679.
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