TY - JOUR
T1 - Effects of peripheral immune activation on social behavior and adrenocortical activity in aggressive mice
T2 - Genotype-environment interactions
AU - Granger, Douglas A.
AU - Hood, Kathryn E.
AU - Ikeda, Sandra C.
AU - Reed, Cheryl L.
AU - Jones, Byron C.
AU - Block, Michelle L.
PY - 1997
Y1 - 1997
N2 - To explore genetic-developmental differences in the biobehavioral effects of induced illness, males from two lines of mice sc lectively bred for high or low levels of aggressive behavior were injected with endotoxin (Escherichia coli, LPS: 0.25 mg/kg, 1.25 mg/kg, or 2.5 mg, i.p.) or saline. Body temperature, weight, and locomotor activity were monitored immediately before and 8 and 24 hr after injection. Twenty-four hours after injection, social behaviors were assessed in a 10-min dyadic test, and hypothalamus, spleen, and serum were collected. In both lines, endotoxin treatment increased behavioral immobility ("freezing") and decreased social exploration. Other effects showed line differences: Males from the high-aggressive line had a lower threshold to endotoxin-induced effects on body temperature, weight loss, spleen weight, and corticosterone. Social reactivity (startle response to mild social investigation) increased in the high-aggressive line and decreased in the low-aggressive line after treatment. In the high-aggressive line only, endotoxin decreased attack frequency and increased latency to attack. The interactions between selected line (genotype) and endotoxin treatment (environment) demonstrate that genetic-developmental differences in social and aggressive behavior may indicate the extent to which immune stimuli (e.g., bacteria, viruses, cytokines) function as "biobehavioral stressors." Aggr. Behav. 23:93-105, 1997.
AB - To explore genetic-developmental differences in the biobehavioral effects of induced illness, males from two lines of mice sc lectively bred for high or low levels of aggressive behavior were injected with endotoxin (Escherichia coli, LPS: 0.25 mg/kg, 1.25 mg/kg, or 2.5 mg, i.p.) or saline. Body temperature, weight, and locomotor activity were monitored immediately before and 8 and 24 hr after injection. Twenty-four hours after injection, social behaviors were assessed in a 10-min dyadic test, and hypothalamus, spleen, and serum were collected. In both lines, endotoxin treatment increased behavioral immobility ("freezing") and decreased social exploration. Other effects showed line differences: Males from the high-aggressive line had a lower threshold to endotoxin-induced effects on body temperature, weight loss, spleen weight, and corticosterone. Social reactivity (startle response to mild social investigation) increased in the high-aggressive line and decreased in the low-aggressive line after treatment. In the high-aggressive line only, endotoxin decreased attack frequency and increased latency to attack. The interactions between selected line (genotype) and endotoxin treatment (environment) demonstrate that genetic-developmental differences in social and aggressive behavior may indicate the extent to which immune stimuli (e.g., bacteria, viruses, cytokines) function as "biobehavioral stressors." Aggr. Behav. 23:93-105, 1997.
KW - Aggressive behavior
KW - Corticosterone
KW - Corticotropin-releasing factor
KW - Endotoxin
KW - Immune response
KW - Psychoneuroimmunology
KW - Selective breeding
UR - http://www.scopus.com/inward/record.url?scp=0031477171&partnerID=8YFLogxK
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U2 - 10.1002/(sici)1098-2337(1997)23:2<93::aid-ab2>3.0.co;2-u
DO - 10.1002/(sici)1098-2337(1997)23:2<93::aid-ab2>3.0.co;2-u
M3 - Article
AN - SCOPUS:0031477171
SN - 0096-140X
VL - 23
SP - 93
EP - 105
JO - Aggressive Behavior
JF - Aggressive Behavior
IS - 2
ER -