Effects of particle size and coating on toxicologic parameters, fecal elimination kinetics and tissue distribution of acutely ingested silver nanoparticles in a mouse model

Ingrid L. Bergin, Laura A. Wilding, Masako Morishita, Kim Walacavage, Andrew P. Ault, Jessica L. Axson, Diana I. Stark, Sara A. Hashway, Sonja S. Capracotta, Pascale R. Leroueil, Andrew Maynard, Martin A. Philbert

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Consumer exposure to silver nanoparticles (AgNP) via ingestion can occur due to incorporation of AgNP into products such as food containers and dietary supplements. AgNP variations in size and coating may affect toxicity, elimination kinetics or tissue distribution. Here, we directly compared acute administration of AgNP of two differing coatings and sizes to mice, using doses of 0.1, 1 and 10 mg/kg body weight/day administered by oral gavage for 3 days. The maximal dose is equivalent to 2000× the EPA oral reference dose. Silver acetate at the same doses was used as ionic silver control. We found no toxicity and no significant tissue accumulation. Additionally, no toxicity was seen when AgNP were dosed concurrently with a broad-spectrum antibiotic. Between 70.5% and 98.6% of the administered silver dose was recovered in feces and particle size and coating differences did not significantly influence fecal silver. Peak fecal silver was detected between 6- and 9-h post-administration and

Original languageEnglish (US)
Pages (from-to)352-360
Number of pages9
JournalNanotoxicology
Volume10
Issue number3
DOIs
StatePublished - Mar 15 2016
Externally publishedYes

Fingerprint

Tissue Distribution
Silver
Particle Size
Nanoparticles
Particle size
Tissue
Coatings
Kinetics
Toxicity
Dietary Supplements
Dietary supplements
Food Packaging
Feces
Containers
Antibiotics
Eating
Body Weight
Anti-Bacterial Agents

Keywords

  • ICP-OES
  • in vivo
  • mouse
  • nanomaterials
  • nanoparticle
  • nanotoxicology
  • silver
  • toxicology

ASJC Scopus subject areas

  • Biomedical Engineering
  • Toxicology

Cite this

Effects of particle size and coating on toxicologic parameters, fecal elimination kinetics and tissue distribution of acutely ingested silver nanoparticles in a mouse model. / Bergin, Ingrid L.; Wilding, Laura A.; Morishita, Masako; Walacavage, Kim; Ault, Andrew P.; Axson, Jessica L.; Stark, Diana I.; Hashway, Sara A.; Capracotta, Sonja S.; Leroueil, Pascale R.; Maynard, Andrew; Philbert, Martin A.

In: Nanotoxicology, Vol. 10, No. 3, 15.03.2016, p. 352-360.

Research output: Contribution to journalArticle

Bergin, IL, Wilding, LA, Morishita, M, Walacavage, K, Ault, AP, Axson, JL, Stark, DI, Hashway, SA, Capracotta, SS, Leroueil, PR, Maynard, A & Philbert, MA 2016, 'Effects of particle size and coating on toxicologic parameters, fecal elimination kinetics and tissue distribution of acutely ingested silver nanoparticles in a mouse model', Nanotoxicology, vol. 10, no. 3, pp. 352-360. https://doi.org/10.3109/17435390.2015.1072588
Bergin, Ingrid L. ; Wilding, Laura A. ; Morishita, Masako ; Walacavage, Kim ; Ault, Andrew P. ; Axson, Jessica L. ; Stark, Diana I. ; Hashway, Sara A. ; Capracotta, Sonja S. ; Leroueil, Pascale R. ; Maynard, Andrew ; Philbert, Martin A. / Effects of particle size and coating on toxicologic parameters, fecal elimination kinetics and tissue distribution of acutely ingested silver nanoparticles in a mouse model. In: Nanotoxicology. 2016 ; Vol. 10, No. 3. pp. 352-360.
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